{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:51:25Z","timestamp":1789426285713,"version":"build-2803163510"},"reference-count":16,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Integr Cancer Ther"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Context: Long-term patient survival in cancer is affected by drug resistance. Honokiol (HNK) is a small-molecule polyphenol isolated from the bark and seed cones of Magnolia officinalis. HNK has been shown to enhance the effects of chemotherapy and inhibit drug resistance in preclinical models. HNK was well tolerated in multiple animal models when administered orally, intravenously (IV), and via intraperitoneal route. However, there are limited human data on the use of HNK in general, and specifically via IV (HNK-IV) in cancer. Objective: We aim to assess the efficacy, safety, and tolerability of HNK-IV in patients with drug-resistant tumors. Methods: This is a case study of 2 cancer patients who utilized HNK-IV as part of their cancer treatment regimen. The initial infusion of HNK was 10 mg\/kg body weight, and subsequent treatments were increased up to 50 mg\/kg according to individual tolerance, over 2 weeks. Results: Positive clinical response was achieved in both patients, including improved symptoms and quality of life. No serious adverse side effects occurred, and there were no adverse effects on laboratory parameters (complete blood count, kidney, and liver function). Transient sedation and minor nausea were noted and resolved postinfusion. Conclusions: This is the first report of HNK-IV in human patients. Given the positive clinical results, safety, and tolerability, the use of HNK-IV warrants further investigation regarding optimum formulation, and its use as adjunctive therapy in cancer patients.<\/jats:p>","DOI":"10.1177\/1534735420922615","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T03:02:30Z","timestamp":1591066950000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Intravenous Honokiol in Drug-Resistant Cancer: Two Case Reports"],"prefix":"10.1177","volume":"19","author":[{"given":"Isaac","family":"Eliaz","sequence":"first","affiliation":[{"name":"Amitabha Medical Clinic and Healing Center, Santa Rosa, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Weil","sequence":"additional","affiliation":[{"name":"Amitabha Medical Clinic and Healing Center, Santa Rosa, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,6,2]]},"reference":[{"key":"bibr1-1534735420922615","doi-asserted-by":"publisher","DOI":"10.1016\/S1040-8428(97)10002-6"},{"key":"bibr2-1534735420922615","unstructured":"American Cancer Society. Survival rates for prostate cancer. https:\/\/www.cancer.org\/cancer\/prostate-cancer\/detection-diagnosis-staging\/survival-rates.html. Accessed December 12, 2019."},{"key":"bibr3-1534735420922615","unstructured":"American Cancer Society. Triple-negative breast cancer. https:\/\/www.cancer.org\/cancer\/breast-cancer\/understanding-a-breast-cancer-diagnosis\/types-of-breast-cancer\/triple-negative.html. Accessed February 7, 2020."},{"key":"bibr4-1534735420922615","unstructured":"American Cancer Society. Breast cancer facts & figures 2019-2020. https:\/\/www.cancer.org\/content\/dam\/cancer-org\/research\/cancer-facts-and-statistics\/breast-cancer-facts-and-figures\/breast-cancer-facts-and-figures-2019-2020.pdf. Published 2019. Accessed December 12, 2019."},{"key":"bibr5-1534735420922615","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2440"},{"key":"bibr6-1534735420922615","doi-asserted-by":"publisher","DOI":"10.2174\/156652412803833508"},{"key":"bibr7-1534735420922615","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2012.1739"},{"key":"bibr8-1534735420922615","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2007.01070.x"},{"key":"bibr9-1534735420922615","first-page":"957","volume":"2","author":"Cheng N","year":"2011","journal-title":"Oncol Lett"},{"key":"bibr10-1534735420922615","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22551"},{"key":"bibr11-1534735420922615","first-page":"197","volume":"24","author":"Angelini A","year":"2010","journal-title":"J Biol Regul Homeost Agents"},{"key":"bibr12-1534735420922615","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086369"},{"key":"bibr13-1534735420922615","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2005.11.031"},{"key":"bibr14-1534735420922615","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-1926"},{"key":"bibr15-1534735420922615","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018490"},{"key":"bibr16-1534735420922615","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2016.02.021"}],"container-title":["Integrative Cancer Therapies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1534735420922615","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1534735420922615","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1534735420922615","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:16:53Z","timestamp":1777454213000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1534735420922615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":16,"alternative-id":["10.1177\/1534735420922615"],"URL":"https:\/\/doi.org\/10.1177\/1534735420922615","relation":{},"ISSN":["1534-7354","1552-695X"],"issn-type":[{"value":"1534-7354","type":"print"},{"value":"1552-695X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"article-number":"1534735420922615"}}