{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T14:30:18Z","timestamp":1782743418358,"version":"3.54.5"},"reference-count":46,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"the National Research Foundation grant funded by the Korea government","award":["2019R1A2C2005157"],"award-info":[{"award-number":["2019R1A2C2005157"]}]},{"DOI":"10.13039\/501100009695","name":"catholic kwandong university","doi-asserted-by":"publisher","award":["CKURF 201805590001"],"award-info":[{"award-number":["CKURF 201805590001"]}],"id":[{"id":"10.13039\/501100009695","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bio-industry Technology Development Program of IPET","award":["316025-05"],"award-info":[{"award-number":["316025-05"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Integr Cancer Ther"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n                    This study investigated the adjuvant effects for anticancer and antifatigue of the combination of Cordyceps militaris extract with sorafenib. The 5 extracts of C militaris were obtained through hexane, chloroform, ethyl acetate, butanol, and water and were evaluated for anticancer growth activity. Among these extracts, ethyl acetate extract of C militaris showed the best tumor growth inhibitory activity and the adjuvant effects in combination with sorafenib. As a result of biochemical analysis with serum, the combination of ethyl acetate extract of C militaris with sorafenib showed the adjuvant effects both improving hepatic function and relieving cancer-related fatigue. In addition,\n                    <jats:sup>1<\/jats:sup>\n                    H-nuclear magnetic resonance\u2013based metabolic profiling in liver tissues showed that the change of metabolism by ethyl acetate extract of C militaris with sorafenib was related with serum fatigue biomarkers. Therefore, the combination strategy such as ethyl acetate extraction of C militaris with sorafenib constitutes a promising therapeutic strategy in hepatocellular carcinoma, via the inhibition of cancer growth, the enhancement of liver function, as well as the alleviation of cancer-related fatigue.\n                  <\/jats:p>","DOI":"10.1177\/1534735420932635","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T01:55:06Z","timestamp":1592877306000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy of Ethyl Acetate Fraction of\n                    <i>Cordyceps militaris<\/i>\n                    for Cancer-Related Fatigue in Blood Biochemical and\n                    <sup>1<\/sup>\n                    H-Nuclear Magnetic Resonance Metabolomic 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