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In vitro MTT cell proliferation assay has shown that the irradiated Ehrlich ascites carcinoma (EAC) cell line could be sensitized by BL pretreatment. In vivo: animals were randomly divided into 5 groups, Group 1: control (PBS i.p for 10\u2009days), Group 2: Ehrlich solid tumor (EST) bearing mice, Group 3: EST\u2009+\u2009\u03b3-radiation (fractionated dose, 1\u2009Gy\u2009\u00d7\u20095), Group 4: EST\u2009+\u2009BL (6\u2009mg\/kg, i.p), daily for 10\u2009days, Group 5: EST\u2009+\u2009BL for 10\u2009days followed by \u03b3-irradiation (1\u2009Gy\u2009\u00d7\u20095). The size and weight of tumors in gamma-irradiated EST bearing mice treated with BL decreased significantly with a significant amelioration in the histopathological examination. Besides, BL mitigated the effect of \u03b3-irradiation on the liver relative gene expression of poly ADP ribose polymerase-1 (PARP1), nuclear factor kappa activated B cells (NF-\u03baB), and peroxisome proliferator-activated receptor \u03b1 (PPAR-\u03b1), and it restored liver function via amelioration of paraoxonase1 (PON1) activity, reactive oxygen species (ROS) content, lipid peroxidation (LPO) and serum aspartate transaminase (AST), alanine transaminase (ALT), and albumin (ALB). It is concluded that BL can be considered as a radio-sensitizer and radio-protector, suggesting a possible role in reducing radiation exposure dose during radiotherapy.<\/jats:p>","DOI":"10.1177\/1534735420950468","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T08:54:04Z","timestamp":1597222444000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Study of the Radiosensitizing and Radioprotective Efficacy of Bromelain (a Pineapple Extract): In Vitro and In Vivo"],"prefix":"10.1177","volume":"19","author":[{"given":"Mai H.","family":"Mekkawy","sequence":"first","affiliation":[{"name":"Drug Radiation Research Department, National Centre for Radiation Research and Technology, Egyptian, Atomic Energy Authority, Nasr City, Cairo, 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