{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:04:00Z","timestamp":1779894240234,"version":"3.53.1"},"reference-count":41,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["8268792905342559"],"award-info":[{"award-number":["8268792905342559"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Integr Cancer Ther"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>We assessed safety and potential efficacy of a chamomile gel compared with urea cream to prevent acute radiation dermatitis in head and neck cancer patients. We assessed safety and potential efficacy of the chamomile gel in escalating concentrations of 2.50%, 5.00% and 8.35% of chamomile. Concentration of 8.35% was chosen for a randomized trial comparing chamomile gel (8.35%) with urea cream (n\u2009=\u200924\u2009per group), for potential efficacy to delay or prevent radiation dermatitis in these patients. Preliminary results demonstrate a delayed onset of dermatitis, with onset of Grade 2 dermatitis at 5.1 (1.3) weeks in the chamomile group and 4.5 (1.3) weeks in the urea group (effect size of 0.46). Itching, burning and hyperpigmentation were more frequently reported in the urea group. Results indicates a potential efficacy of the chamomile gel. Further studies are needed to confirm the effect of the chamomile gel in reducing or delaying the occurrence of radiation dermatitis.<\/jats:p>","DOI":"10.1177\/1534735420962174","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T02:50:07Z","timestamp":1601261407000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Chamomile Gel versus Urea Cream to Prevent Acute Radiation Dermatitis in Head and Neck Cancer Patients: Results from a Preliminary Clinical Trial"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0428-834X","authenticated-orcid":false,"given":"Elaine B.","family":"Ferreira","sequence":"first","affiliation":[{"name":"University of Bras\u00edlia, Bras\u00edlia, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia A.","family":"Ciol","sequence":"additional","affiliation":[{"name":"University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda G.","family":"de Meneses","sequence":"additional","affiliation":[{"name":"University of Bras\u00edlia, Bras\u00edlia, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila de S. M.","family":"Bontempo","sequence":"additional","affiliation":[{"name":"University of Bras\u00edlia, Bras\u00edlia, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne M.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula E. D. dos","family":"Reis","sequence":"additional","affiliation":[{"name":"University of Bras\u00edlia, Bras\u00edlia, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,9,27]]},"reference":[{"key":"bibr1-1534735420962174","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1007\/s00520-017-3569-z","volume":"25","author":"Iacovelli NA","year":"2017","journal-title":"Support Care Cancer"},{"key":"bibr2-1534735420962174","first-page":"551","volume":"9","author":"Seit\u00e9 S","year":"2017","journal-title":"Breast Cancer"},{"key":"bibr3-1534735420962174","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.ijrobp.2017.07.019","volume":"99","author":"Tao Y","year":"2017","journal-title":"Int J Radiat Oncol"},{"key":"bibr4-1534735420962174","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.12213"},{"key":"bibr5-1534735420962174","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13507"},{"key":"bibr6-1534735420962174","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/s12885-018-4119-x","volume":"18","author":"Narvaez C","year":"2018","journal-title":"BMC Cancer"},{"key":"bibr7-1534735420962174","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-016-3521-7"},{"key":"bibr8-1534735420962174","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1590\/S0104-11692011000100002","volume":"19","author":"Reis PED","year":"2011","journal-title":"Rev Lat Am Enfermagem"},{"key":"bibr9-1534735420962174","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-016-0186-4"},{"key":"bibr10-1534735420962174","doi-asserted-by":"crossref","first-page":"104267","DOI":"10.1016\/j.fitote.2019.104267","volume":"138","author":"Santos DS","year":"2019","journal-title":"Fitote"},{"key":"bibr11-1534735420962174","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/ptr.3245","volume":"25","author":"Arsi\u0107 I","year":"2011","journal-title":"Phytother Res"},{"key":"bibr12-1534735420962174","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1111\/j.1365-4632.2011.05235.x","volume":"51","author":"Shimelis ND","year":"2012","journal-title":"Int J Dermatol"},{"key":"bibr13-1534735420962174","first-page":"28","volume":"57","author":"Charousaei F","year":"2011","journal-title":"Ostomy Wound Manage"},{"key":"bibr14-1534735420962174","doi-asserted-by":"publisher","DOI":"10.1007\/BF00316465"},{"key":"bibr15-1534735420962174","doi-asserted-by":"publisher","DOI":"10.1177\/1203475417743234"},{"key":"bibr16-1534735420962174","unstructured":"REIS, P.E.D. Therapeutic Topic Use of Chamomilla Recutita in Phlebitis Due to Peripheral Intravenous Therapy [Doctoral thesis]. University of S\u00e3o Paulo at Ribeir\u00e3o Preto College of Nursing, Ribeir\u00e3o Preto, SP, Brasil, 2008: 229."},{"key":"bibr17-1534735420962174","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1111\/jan.12955","volume":"72","author":"Ferreira EB","year":"2016","journal-title":"J Adv Nurs"},{"key":"bibr18-1534735420962174","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-12-103"},{"key":"bibr19-1534735420962174","unstructured":"World Health Organization. WHO monographs on selected medicinal plants, vol 1. World Heal Organization. 1999:1. https:\/\/apps.who.int\/medicinedocs\/pdf\/s2200e\/s2200e.pdf. Accessed March 24, 2019."},{"key":"bibr20-1534735420962174","unstructured":"Minist\u00e9rio da Sa\u00fade. Ag\u00eancia Nacional de Vigil\u00e2ncia Sanit\u00e1ria. [Resolution - RDC No. 14, of March 31, 2010. 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