{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:35:16Z","timestamp":1792787716001,"version":"4.5.0"},"reference-count":65,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Limoges Hospital Ethics Committee","award":["2012-A01401-42"],"award-info":[{"award-number":["2012-A01401-42"]}]},{"name":"Declaration of Helsinki","award":["No Award Number"],"award-info":[{"award-number":["No Award Number"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Integr Cancer Ther"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Physical activity (PA) programs are recommended for breast cancer care. However, their modalities remain to be discussed. This study determined the best time to begin a personalized or adapted program based on cardiopulmonary exercise test function. This randomized controlled trial evaluated the effect of home-based adapted PA (APA) performed during or after treatment on cardiorespiratory fitness (CRF) at 12\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>\n                      The primary endpoint was the peak oxygen consumption (VO\n                      <jats:sub>2peak<\/jats:sub>\n                      ) at 12\u2009months (group A vs C and B vs C). Secondary endpoints included the 6-minute walking test, assessment of muscle strength, fatigue, quality of life, anxiety, and depression, and a questionnaire on PA levels. All tests were evaluated at baseline and at 6 and 12\u2009months. A total of 94 patients with breast cancer were randomized to 3 different groups: group A, performing 6\u2009months of APA during adjuvant care; group B, 6\u2009months of APA after adjuvant care; and group C, 12\u2009months of APA during and after specific care. The program combined 1 resistance session and 2 aerobic sessions per week. Analysis of variance was used for repeated measures, Student\u2019s t-test or the Mann\u2013Whitney U-test for continuous variables, and \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      test for binary or categorical variables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The study assessed 81 participants at 6\u2009months and 73 at 12\u2009months. The majority of patients completed more than 85% of the exercise sessions. The baseline for VO\n                      <jats:sub>2peak<\/jats:sub>\n                      and secondary outcomes did not differ among the groups. VO\n                      <jats:sub>2peak<\/jats:sub>\n                      increased during the exercise period and decreased during the chemotherapy period without APA, but at 12\u2009months no significant difference was observed. The same variation was observed in the 6-minute walking test, with significance at 6\u2009months between A+C versus B ( P\u2009=\u2009.04), but no difference among the groups at 12\u2009months. In the 3 groups, no decreases in other studied parameters were noted, except at 6\u2009months in group B without APA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Home-based APA in breast cancer patients has a positive effect on CRF and physical functions, with no differences based on the timing of this program based on specific cancer treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration:<\/jats:title>\n                    <jats:p>ClinicalTrials.gouv.fr (NCT01795612). Registered 20 February 2013.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1534735420969818","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:43:07Z","timestamp":1606178587000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Home-Based Physical Activity in Patients With Breast Cancer: During and\/or After Chemotherapy? Impact on Cardiorespiratory Fitness. A 3-Arm Randomized Controlled Trial (APAC)"],"prefix":"10.1177","volume":"19","author":[{"given":"Fran\u00e7ois","family":"Vincent","sequence":"first","affiliation":[{"name":"Department of Physiology, University Hospital, Limoges, France"},{"name":"Faculty of Medicine, University of Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8474-3116","authenticated-orcid":false,"given":"Elise","family":"Deluche","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Limoges, Limoges, France"},{"name":"Department of Medical Oncology, University Hospital, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00eblle","family":"Bonis","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Leobon","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Clinical Research, University Hospital, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Th\u00e9r\u00e8se","family":"Antonini","sequence":"additional","affiliation":[{"name":"Department of Physiology, University Hospital, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Laval","sequence":"additional","affiliation":[{"name":"Department of Physiology, University Hospital, Limoges, France"},{"name":"Faculty of Medicine, University of Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Favard","sequence":"additional","affiliation":[{"name":"Department of Physiology, University Hospital, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elo\u00efse","family":"Dobbels","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Clinical Research, University Hospital, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Lavau-Denes","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Clinical Research, University Hospital, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana\u00efs","family":"Labrunie","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Clinical Research, University Hospital, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Thuillier","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Clinical Research, University Hospital, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Venat","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Clinical Research, University Hospital, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Tubiana-Mathieu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Limoges, Limoges, France"},{"name":"Department of Medical Oncology, University Hospital, Limoges, France"},{"name":"Department of Biostatistics and Clinical Research, University Hospital, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,11,23]]},"reference":[{"key":"bibr1-1534735420969818","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-009-0110-5"},{"key":"bibr2-1534735420969818","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-04-0703"},{"key":"bibr3-1534735420969818","doi-asserted-by":"publisher","DOI":"10.1093\/epirev\/mxx007"},{"key":"bibr4-1534735420969818","doi-asserted-by":"publisher","DOI":"10.1177\/1534735416683807"},{"key":"bibr5-1534735420969818","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2017.04.003"},{"key":"bibr6-1534735420969818","volume-title":"Exercise Motivation VJK. 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