{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:27:07Z","timestamp":1778891227741,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004681","name":"Higher Education Commission, Pakistan","doi-asserted-by":"publisher","award":["117-5638-BM7-028"],"award-info":[{"award-number":["117-5638-BM7-028"]}],"id":[{"id":"10.13039\/501100004681","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Integr Cancer Ther"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Context:<\/jats:title>\n                    <jats:p>Carcinogenesis causes much human misery. It is a process involving multistage alterations. Medicinal plants are candidates for beneficial anticancer agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Investigation of anticancer proficiencies of the plant Dicliptera roxburghiana.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods:<\/jats:title>\n                    <jats:p>Crude extract and derived fractions were inspected for their inhibitory potential against nuclear factor KB (NF\u03baB), nitric oxide synthase inhibition, aromatase inhibition and induction of quinone reductase 1 (QR 1). Antiproliferative activity was determined by using various cancer cell lines for example hormone responsive breast cancer cell line MCF-7, estrogen receptor negative breast cancer cell line MDA-MB-231, murine hepatoma cells Hepa 1c1c7, human neuroblastoma cells SK-N-SH and neuroblastoma cells MYCN-2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Ethyl acetate and n-butanol fractions of D. roxburghiana were strongly active against NF\u03baB with IC\n                      <jats:sub>50<\/jats:sub>\n                      of 16.6\u2009\u00b1\u20091.3 and 8.4\u2009\u00b1\u20090.7\u2009\u00b5g\/ml respectively with 100% survival. Chloroform fraction of the plant exhibited an induction ratio of 2.4\u2009\u00b1\u20090.09 with CD value of 17.7\u2009\u00b5g\/ml. Regarding the nitrite assay, the n-hexane fraction exhibited significant inhibition of NO activity with IC\n                      <jats:sub>50<\/jats:sub>\n                      of 17.8\u2009\u00b1\u20091.25\u2009\u00b5g\/ml. The n-butanol fraction exhibited strong antiproliferative activity against IcIc-7 cell lines with IC\n                      <jats:sub>50<\/jats:sub>\n                      values of 13.6\u2009\u00b1\u20091.91\u2009\u00b5g\/ml; against MYCN-2 a cytotoxic effect developed with dose dependence, with IC\n                      <jats:sub>50<\/jats:sub>\n                      of 12.6\u2009\u00b1\u20091.24\u2009\u00b5g\/ml. In antiproliferative activity against SK-N-SH cell lines, chloroform, ethyl acetate and n-butanol fractions were efficiently active with IC\n                      <jats:sub>50<\/jats:sub>\n                      values of 11.2\u2009\u00b1\u20090.84, 14.6\u2009\u00b1\u20091.71 and 16.3\u2009\u00b1\u20091.57 respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and Conclusion:<\/jats:title>\n                    <jats:p>It was demonstrated that various fractions of D. roxburghiana displayed appreciable anticancer characteristics and could be a potent source for the development of anticancer leads.<\/jats:p>\n                  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