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The goal of this study was to assess chrysin immune-stimulating and pro-apoptotic effects on tumor growth and cell susceptibility to ionizing radiation in order to improve cancer therapy. Chrysin (20\u2009mg\/kg\/day) was intraperitoneally injected to mice bearing 1\u2009cm\n                    <jats:sup>3<\/jats:sup>\n                    solid tumor of Ehrlich ascites carcinoma (EAC) for 21 consecutive days. Mice were whole body exposed to 1\u2009Gy of gamma radiation (2 fractionated dose 0.5\u2009Gy each). Treatment with chrysin dramatically reduces tumor proliferation in EAC mice; furthermore, IFN-\u03b3 activity is significantly reduced when compared to EAC mice. When compared to EAC mice, the expression of TNF-\u03b1, free radicals, and nitric oxide (NO) levels were considerably reduced, along with improvements in apoptotic regulators (caspase-3 activity). Moreover, the histopathological investigation confirms the improvement exerted by chrysin even in the EAC mice group or the EAC\u2009+\u2009R group. What is more, exposure to gamma radiation sustained the modulatory effect of chrysin on tumor when compared with EAC\u2009+\u2009Ch mice. Hence, chrysin might represent a potential therapeutic strategy for increasing the radiation response of solid tumor.\n                  <\/jats:p>","DOI":"10.1177\/15347354221096668","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T08:07:30Z","timestamp":1652256450000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Immune Stimulating Outcome of Chrysin and \u03b3-Irradiation via Apoptotic Activation Against Solid Ehrlich Carcinoma Bearing Mice"],"prefix":"10.1177","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0128-3159","authenticated-orcid":false,"given":"Nermeen M.","family":"El Bakary","sequence":"first","affiliation":[{"name":"National Centre for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa Z.","family":"Alsharkawy","sequence":"additional","affiliation":[{"name":"Al-Azhar University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab A.","family":"Shouaib","sequence":"additional","affiliation":[{"name":"Al-Azhar University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad M.S.","family":"Barakat","sequence":"additional","affiliation":[{"name":"Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,5,11]]},"reference":[{"key":"bibr1-15347354221096668","doi-asserted-by":"publisher","DOI":"10.3390\/biom10101374"},{"key":"bibr2-15347354221096668","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-01906-y"},{"key":"bibr3-15347354221096668","doi-asserted-by":"publisher","DOI":"10.3390\/nu13082594"},{"key":"bibr4-15347354221096668","first-page":"1","volume":"9","author":"El Bakary NM","year":"2021","journal-title":"Int J Clin Stud Med Case Rep"},{"key":"bibr5-15347354221096668","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10010071"},{"key":"bibr6-15347354221096668","first-page":"1","volume":"5","author":"El Bakary NM","year":"2021","journal-title":"J Cancer Res Cell Ther"},{"key":"bibr7-15347354221096668","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/63353075"},{"key":"bibr8-15347354221096668","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/20014091111721","volume":"31","author":"Calabrese EJ","year":"2001","journal-title":"Crit Rev Toxicol"},{"key":"bibr9-15347354221096668","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-34400"},{"key":"bibr10-15347354221096668","doi-asserted-by":"publisher","DOI":"10.1177\/1534735420944476"},{"key":"bibr11-15347354221096668","first-page":"45","volume":"9","author":"Papadopoulos D","year":"1989","journal-title":"Anticancer Res"},{"key":"bibr12-15347354221096668","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"bibr13-15347354221096668","doi-asserted-by":"publisher","DOI":"10.1006\/niox.2000.0319"},{"key":"bibr14-15347354221096668","doi-asserted-by":"publisher","DOI":"10.1139\/v82-501"},{"key":"bibr15-15347354221096668","unstructured":"Bancroft JD, Stevens A, Dawswon MP. 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