{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T11:59:41Z","timestamp":1794571181838,"version":"4.9.1"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Integr Cancer Ther"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Non-cancer drugs are currently being repurposed for cancer treatment. Mounting evidence highlights the influence of calcium channels on tumorigenesis and progression. Hence, inhibition of calcium signaling may be a promising cancer treatment strategy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>In this study, we aimed to examine whether calcium channel blockers (CCBs) affect the efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in patients with non-small cell lung cancer (NSCLC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>We conducted a retrospective analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this study, conducted between January 2009 and June 2021, patients with NSCLC treated with erlotinib, or gefitinib for at least 1\u2009week were enrolled and divided into 2 groups: CCBs-\/EGFR-TKIs+ and CCBs+\/EGFR-TKIs+, depending on whether they received CCB therapy. Progression-free survival (PFS) and overall survival (OS) were determined as the primary and secondary endpoints, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>: The estimated median PFS and OS for the CCBs-\/EGFR-TKIs+group were 7.70 and 12.17\u2009months, respectively, and they were significantly different from those of the CCBs+\/EGFR-TKIs+ group (10.43 and 18.07\u2009months, respectively). CCB use was associated with improved PFS (adjusted hazard ratios [HR] 0.77, 95% confidence interval [CI]: 0.61-0.98; P\u2009=\u2009.035) and OS (adjusted HR 0.66, 95% CI: 0.51-0.84; P\u2009&lt;\u2009.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Calcium channels have been implicated in cancer pathogenesis. Our findings revealed the potential additive anticancer effects of CCBs when used concomitantly with EGFR-TKIs. However, study limitations, including the retrospective nature and small number of patients, necessitate large-scale prospective studies on the therapeutic potential of CCB as an adjunctive therapy with EGFR-TKIs in patients with NSCLC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15347354231178903","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T01:51:02Z","timestamp":1686275462000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Survival Outcomes of Calcium Channel Blocker Therapy in Patients With Non-Small Cell Lung Cancer Treated With Epidermal Growth Factor Receptor Inhibitors: A Retrospective Study"],"prefix":"10.1177","volume":"22","author":[{"given":"Hui-Hsia","family":"Hsieh","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan, R.O.C."},{"name":"School of Pharmacy, China Medical University, Taichung, Taiwan, R.O.C."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5205-4567","authenticated-orcid":false,"given":"Tien-Yuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan, R.O.C."},{"name":"Graduate Institute of Clinical Pharmacy, Tzu Chi University, Hualien, Taiwan, R.O.C."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Hua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan, R.O.C."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hung","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Research, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan, R.O.C."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6714-8788","authenticated-orcid":false,"given":"Mann-Jen","family":"Hour","sequence":"additional","affiliation":[{"name":"School of Pharmacy, China Medical University, Taichung, Taiwan, R.O.C."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,6,8]]},"reference":[{"key":"bibr1-15347354231178903","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21654"},{"key":"bibr2-15347354231178903","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S85173"},{"key":"bibr3-15347354231178903","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000033"},{"key":"bibr4-15347354231178903","doi-asserted-by":"publisher","DOI":"10.1038\/nature13385"},{"key":"bibr5-15347354231178903","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810699"},{"key":"bibr6-15347354231178903","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70393-X"},{"key":"bibr7-15347354231178903","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27396"},{"key":"bibr8-15347354231178903","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.13749"},{"key":"bibr9-15347354231178903","doi-asserted-by":"publisher","DOI":"10.1253\/circj.cj-08-0188"},{"key":"bibr10-15347354231178903","doi-asserted-by":"publisher","DOI":"10.1177\/1060028018814684"},{"issue":"1","key":"bibr11-15347354231178903","first-page":"52","volume":"2","author":"Yang 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