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In the search for treatment options, natural products used in Chinese herbal medicines (CHMs) have received attention in clinical studies for their effects on cancer-related pain. The objective of this systematic review is to evaluate the clinical evidence for topically applied CHMs as adjunctive treatments for cancer pain management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Nine biomedical databases and 4 clinical trial registries were searched for randomized-controlled trials (RCTs) that reported measures of pain and\/or quality of life. Risk of bias was assessed using the Cochrane tool. Meta-analysis employed mean difference (MD) with 95% confidence intervals (random effects).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Twenty (20) RCTs (1636 participants) met the inclusion criteria. Meta-analyses were grouped based on the comparisons and outcome measures. For pain intensity, there was a greater reduction in the topical CHM group versus placebo (MD \u22120.72 [\u22121.04, \u22120.40]), no difference when compared to tramadol (MD \u22120.15 [\u22120.38, 0.08]), and a greater reduction when topical CHMs were combined with conventional analgesic medications (MD \u22120.67 [\u22120.93, \u22120.40]). Analgesic onset time was reduced in the CHM group compared to tramadol (MD \u221226.02 [\u221227.57, \u221224.47] minutes), and for CHMs combined with conventional medications (MD \u221219.17 [\u221221.83, \u221216.52] minutes). When CHMs were combined with analgesic medications, improvements were found for duration of analgesia (MD 1.65 [0.78, 2.51] hours), analgesic maintenance dose (MD \u221231.72 [\u221250.43, \u221213.01] milligrams\/day), and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Addition of topical CHMs to conventional analgesic medications was associated with improved outcomes for pain intensity, some other pain-related outcomes, and measures of quality of life. Limitations included methodological issues in some studies and considerable heterogeneity in some pooled results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15347354231210870","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T06:27:46Z","timestamp":1699943266000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Topical Traditional Chinese Medicines for Cancer Pain: A Systematic Review and Meta-analysis of Randomized Controlled Trials"],"prefix":"10.1177","volume":"22","author":[{"given":"Yihong","family":"Liu","sequence":"first","affiliation":[{"name":"Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, and The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian 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Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, and The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"The China-Australia International Research Centre for Chinese Medicine, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanjian","family":"Lu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, and The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlie Changli","family":"Xue","sequence":"additional","affiliation":[{"name":"Guangdong Provincial 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