{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:56:48Z","timestamp":1787165808104,"version":"build-2736575974"},"reference-count":26,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"coordena\u00e7\u00e3o de aperfei\u00e7oamento de pessoal de ni\u00edvel superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Integr Cancer Ther"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>evaluate the efficacy of Zingiber Officinale in the management of nausea and vomiting induced by treatment with cisplatin associated with radiotherapy in patients with uterine cervical neoplasms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>a triple-blind, randomized, placebo-controlled trial. Interventions: Comparing the effects of ginger with institutional antiemetic therapy (ondansetron with dexamethasone). Patients with cervical cancer who started treatment with cisplatin with an indication of 40\u2009mg\/m\u00b2 associated with radiotherapy, aged over 18\u2009years, and with the ability to tolerate swallowing a capsule were recruited and equally allocated (1:1:1) into 3 groups of 16 patients each (the ginger capsules 250\u2009mg group, ginger capsules 500\u2009mg group, and placebo group). Nausea and vomiting were measured on baseline, 7\u2009days after the first dose of medication and every seven consecutive days during a treatment break.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The 250\u2009mg ginger group had an 8.0% greater chance of experiencing nausea within 24\u2009h after the chemotherapy infusion than the placebo group, although there is no statistical significance ( P\u2009=\u2009.92986). The 500\u2009mg ginger group showed a 63.9% reduction in nausea under the same conditions ( P\u2009=\u2009.40460). No change was detected in the occurrence of nausea episodes during the 6\u2009weeks ( P\u2009=\u2009.8664) or between the groups ( P\u2009=\u2009.2817). No change was detected in acute or late vomiting during the 6\u2009weeks ( P\u2009=\u2009.3510) or between the groups ( P\u2009=\u2009.8500 and P\u2009=\u2009.5389, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Ginger supplementation does not reduce the intensity of acute and late nausea and vomiting. REBEC (RBR-47yx6p9).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15347354231220608","type":"journal-article","created":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T03:12:06Z","timestamp":1703301126000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of\n                    <i>Zingiber Officinale<\/i>\n                    in the Management of Nausea and Vomiting Induced by Treatment With Cisplatin Associated With Radiotherapy: A Randomized Controlled Trial"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4679-1840","authenticated-orcid":false,"given":"Kauanny Vitoria Gurgel dos","family":"Santos","sequence":"first","affiliation":[{"name":"Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7521-1791","authenticated-orcid":false,"given":"Romeika Lorena Mendes","family":"da Silva","sequence":"additional","affiliation":[{"name":"Institute of Education, Research and Innovation, Liga Contra o C\u00e2ncer, Natal, Rio Grande do Norte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9131-1952","authenticated-orcid":false,"given":"Ayane Cristine Alves","family":"Sarmento","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4105-7535","authenticated-orcid":false,"given":"Kleyton Santos de","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil"},{"name":"Institute of Education, Research and Innovation, Liga Contra o C\u00e2ncer, Natal, Rio Grande do Norte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Lima","family":"Pessoa","sequence":"additional","affiliation":[{"name":"Institute of Education, Research and Innovation, Liga Contra o C\u00e2ncer, Natal, Rio Grande do Norte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0307-2424","authenticated-orcid":false,"given":"Daniele Vieira","family":"Dantas","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9309-2092","authenticated-orcid":false,"given":"Rodrigo Assis Neves","family":"Dantas","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,12,23]]},"reference":[{"key":"bibr1-15347354231220608","unstructured":"Cancer Today. 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