{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:16:05Z","timestamp":1777695365159,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"MycoMagic Biotechnology Co., Ltd., New Taipei City, Taiwan","award":["IAC-11001"],"award-info":[{"award-number":["IAC-11001"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Integr Cancer Ther"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To evaluate the effects of Reishimmune-S, a fungal immunomodulatory peptide, on the quality of life (QoL) and natural killer (NK) cell subpopulations in patients receiving adjuvant endocrine therapy (ET) for breast cancer (BC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients who received adjuvant ET for stage I-III hormone receptor-positive BC without active infection were enrolled in this prospective pilot study. Reishimmune-S was administered sublingually daily for 6\u2009months. QoL scores, circulating immune cell levels, including lymphocyte\/NK cell subpopulations, and plasma levels of interleukin (IL)-6 and tumor necrosis factor (TNF)-\u03b1 were measured at baseline and every 4\u2009weeks. Data were analyzed using linear mixed-effect regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Nineteen participants were included in the analyses. One patient with underlying asthma did not complete the study owing to the occurrence of skin rashes 15\u2009days after the initiation of Reishimmune-S. No other adverse events were reported. Reishimmune-S supplementation significantly improved the cognitive function at 3\u2009months and significantly decreased the fatigue and insomnia levels at 3 and 6\u2009months, respectively. There was no significant change in the global health\/QoL score between baseline and week 4 of treatment. The proportion of CD19\n                      <jats:sup>+<\/jats:sup>\n                      lymphocytes was significantly higher at 3 and 6\u2009months, and that of NKG2A\n                      <jats:sup>+<\/jats:sup>\n                      and NKp30\n                      <jats:sup>+<\/jats:sup>\n                      NK cells was significantly lower at 6\u2009months than at baseline. In addition, fatigue positively correlated with the proportion of NKp30\n                      <jats:sup>+<\/jats:sup>\n                      NK cells (\u03b2\u2009\u00b1\u2009standard error: 24.48\u2009\u00b1\u20098.75, P\u2009=\u2009.007 in the mixed-effect model).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Short-term supplementation with Reishimmune-S affected the circulating immune cell composition and exerted positive effects on cognitive function, fatigue, and insomnia in patients with BC undergoing adjuvant ET, providing a potential approach for the management of treatment-related adverse reactions in this patient population.<\/jats:p>\n                  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