{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:44:49Z","timestamp":1790181889604,"version":"4.1.0"},"reference-count":97,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chinese Medicine Centre","award":["Research Fund"],"award-info":[{"award-number":["Research Fund"]}]},{"DOI":"10.13039\/501100018822","name":"Western Sydney University","doi-asserted-by":"publisher","award":["Research Training Program Fund"],"award-info":[{"award-number":["Research Training Program Fund"]}],"id":[{"id":"10.13039\/501100018822","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Integr Cancer Ther"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Cancer-related fatigue and its associated symptoms of sleep disorder and depression are prevalent in cancer survivors especially among breast, lung, and colorectal cancer survivors. While there is no gold standard for treating cancer-related fatigue currently, studies of mind-body exercises such as Qigong have reported promise in reducing symptoms. This study was designed to evaluate the feasibility and effect of Guolin Qigong on cancer-related fatigue and other symptoms in breast, lung and colorectal cancer survivors while exploring their perceptions and experiences of Guolin Qigong intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This is an open-label randomized controlled trial with 60 participants divided into 2 study groups in a 1:1 ratio. The intervention group will receive 12\u2009weeks of Guolin Qigong intervention with a 4-week follow-up while control will receive usual care under waitlist. The primary outcome will be feasibility measured based on recruitment and retention rates, class attendance, home practice adherence, nature, and quantum of missing data as well as safety. The secondary subjective outcomes of fatigue, sleep quality and depression will be measured at Week-1 (baseline), Week-6 (mid-intervention), Week-12 (post-intervention), and Week-16 (4\u2009weeks post-intervention) while an objective 24-hour urine cortisol will be measured at Week-1 (baseline) and Week-12 (post-intervention). We will conduct a semi-structured interview individually with participants within 3\u2009months after Week-16 (4\u2009weeks post-intervention) to obtain a more comprehensive view of practice adherence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>This is the first mixed-method study to investigate the feasibility and effect of Guolin Qigong on breast, lung, and colorectal cancer survivors to provide a comprehensive understanding of Guolin Qigong\u2019s intervention impact and participants\u2019 perspectives. The interdisciplinary collaboration between Western Medicine and Chinese Medicine expertise of this study ensures robust study design, enhanced participant care, rigorous data analysis, and meaningful interpretation of results. This innovative research contributes to the field of oncology and may guide future evidence-based mind-body interventions to improve cancer survivorship.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration:<\/jats:title>\n                    <jats:p>This study has been registered with ANZCTR (ACTRN12622000688785p), was approved by Medical Research Ethic Committee of University Malaya Medical Centre (MREC ID NO: 2022323-11092) and recognized by Western Sydney University Human Research Ethics Committee (RH15124).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15347354241252698","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T08:08:05Z","timestamp":1715933285000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Exploring Guolin Qigong (Mind-Body Exercise) for Improving Cancer Related Fatigue in Cancer Survivors: A Mixed Method Randomized Controlled Trial Protocol"],"prefix":"10.1177","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6296-6052","authenticated-orcid":false,"given":"Sara L. K.","family":"Low","sequence":"first","affiliation":[{"name":"Western Sydney University, Penrith South, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwo Fuang","family":"Ho","sequence":"additional","affiliation":[{"name":"University Malaya Medical Centre, Kuala Lumpur, Wilayah Persekutuan, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingkai","family":"Liu","sequence":"additional","affiliation":[{"name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eng-Siew","family":"Koh","sequence":"additional","affiliation":[{"name":"University of New South Wales, Liverpool, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Fei","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1071-443X","authenticated-orcid":false,"given":"Chiah Shean","family":"Teo","sequence":"additional","affiliation":[{"name":"UCSI University, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2909-5926","authenticated-orcid":false,"given":"Xiaoshu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Western Sydney University, Penrith South, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,5,17]]},"reference":[{"key":"bibr1-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0b013e318291bd2d"},{"key":"bibr2-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2014.06.003"},{"key":"bibr3-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-015-0450-2"},{"key":"bibr4-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184360"},{"key":"bibr5-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.01579"},{"key":"bibr6-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-007-0380-2"},{"key":"bibr7-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002116"},{"key":"bibr8-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000097"},{"key":"bibr9-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2004.06.003"},{"key":"bibr10-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2020.104648"},{"key":"bibr11-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1177\/1043659620926537"},{"key":"bibr12-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25299"},{"key":"bibr13-15347354241252698","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3402\/ejpt.v3i0.19486","volume":"3","author":"Spiegel D","year":"2012","journal-title":"Eur J Psychotraumatol"},{"key":"bibr14-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2013.05.004"},{"key":"bibr15-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-016-3864-2"},{"key":"bibr16-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2009.07.007"},{"key":"bibr17-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2014.06.171"},{"key":"bibr18-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31570"},{"key":"bibr19-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.12.994"},{"key":"bibr20-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.12.014"},{"key":"bibr21-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.07.019"},{"key":"bibr22-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1159\/000501127"},{"key":"bibr23-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2014.127"},{"key":"bibr24-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2020.103707"},{"key":"bibr25-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2004.01.012"},{"key":"bibr26-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0000000000001048"},{"key":"bibr27-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz276.015"},{"key":"bibr28-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2014.09.009"},{"key":"bibr29-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-011-0205-7"},{"key":"bibr30-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.1154"},{"key":"bibr31-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2012.07.019"},{"key":"bibr32-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2009.09.019"},{"key":"bibr33-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100903"},{"key":"bibr34-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-014-0395-x"},{"key":"bibr35-15347354241252698","doi-asserted-by":"publisher","DOI":"10.4103\/crst.crst_194_22"},{"key":"bibr36-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4273"},{"key":"bibr37-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctcp.2019.101078"},{"key":"bibr38-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-019-0786-2"},{"key":"bibr39-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-017-0665-5"},{"key":"bibr40-15347354241252698","first-page":"881","volume":"62","author":"Huston P","year":"2016","journal-title":"Can Fam Physician"},{"key":"bibr41-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-04911-0"},{"key":"bibr42-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2021.06.036"},{"key":"bibr43-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-018-4136-y"},{"key":"bibr44-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1177\/1534735416686687"},{"key":"bibr45-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2016.10.006"},{"key":"bibr46-15347354241252698","doi-asserted-by":"publisher","DOI":"10.3390\/medicines4010002"},{"key":"bibr47-15347354241252698","first-page":"3209","volume":"24","author":"Klein PJ","year":"2016","journal-title":"Support Care Cancer"},{"key":"bibr48-15347354241252698","first-page":"79","volume-title":"Recent Advances in Theories and Practice of Chinese Medicine","volume":"2012","author":"Xing TL"},{"key":"bibr49-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2015.10.012"},{"key":"bibr50-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27904"},{"key":"bibr51-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1177\/1534735420977671"},{"key":"bibr52-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2014.05.005"},{"key":"bibr53-15347354241252698","first-page":"222","volume":"29","author":"Rodrigues JM","year":"2023","journal-title":"Altern Ther Health Med"},{"key":"bibr54-15347354241252698","author":"Yuan YD.","year":"1994","journal-title":"\u764c\u75c7\u75c5\u53cb\u5eb7\u590d\u65b0\u8def \u3010The New Recovery Path for Cancer Friends]"},{"key":"bibr55-15347354241252698","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2019.20.6.1661"},{"key":"bibr56-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1123\/jpah.2012-0339"},{"key":"bibr57-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.612"},{"key":"bibr58-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1188\/15.ONF.E54-E62"},{"key":"bibr59-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2016.356"},{"key":"bibr60-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0165801"},{"key":"bibr61-15347354241252698","volume":"96","author":"Wu WJ","year":"2017","journal-title":"Medicine"},{"key":"bibr62-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/mzm042"},{"key":"bibr63-15347354241252698","doi-asserted-by":"crossref","DOI":"10.1177\/1534735413485418","volume":"12","author":"Campo RA","year":"2013","journal-title":"Integr Cancer Ther"},{"key":"bibr64-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1007\/s12160-014-9645-4"},{"key":"bibr65-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-013-0315-5"},{"key":"bibr66-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e7586"},{"key":"bibr67-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i5239"},{"key":"bibr68-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990301)85:5<1186::AID-CNCR24>3.0.CO;2-N"},{"key":"bibr69-15347354241252698","unstructured":"National Cancer Institute. About Cancer Survivorship Research: Survivorship Definitions. National Cancer Institute. Published 2022. Updated 17 November 2022. Accessed January 14, 2024.\u2009https:\/\/cancercontrol.cancer.gov\/ocs\/definitions"},{"key":"bibr70-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4447"},{"key":"bibr71-15347354241252698","unstructured":"Sealed Envelope. Minisation. 2022. Updated 31 May 2022. Accessed August 5, 2023. https:\/\/www.sealedenvelope.com\/help\/redpill\/latest\/minimisation\/"},{"key":"bibr72-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1974155443"},{"key":"bibr73-15347354241252698","author":"Yang J-M.","year":"1989","journal-title":"The Root of Chinese Chi Kung: The Secrets of Chi Kung Training"},{"key":"bibr74-15347354241252698","volume-title":"The Way of Qigong","author":"Cohen KS.","year":"1999"},{"key":"bibr75-15347354241252698","volume-title":"Guidance: Safety monitoring and reporting in clinical trials involving therapeutic goods","author":"National Health and Medical Research Council","year":"2016"},{"key":"bibr76-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90047-4"},{"key":"bibr77-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610299005694"},{"key":"bibr78-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1177\/0013164493053004024"},{"key":"bibr79-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(02)00330-6"},{"key":"bibr80-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1995.tb07415.x"},{"key":"bibr81-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1177\/014662167700100306"},{"key":"bibr82-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-3797(18)30622-6"},{"key":"bibr83-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1177\/0004563216687335"},{"key":"bibr84-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-62-5-965"},{"key":"bibr85-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(03)00286-8"},{"key":"bibr86-15347354241252698","volume-title":"Research Design : Qualitative, Quantitative, and Mixed Methods Approaches","author":"Creswell JW","year":"2023","edition":"6"},{"key":"bibr87-15347354241252698","unstructured":"International Conference on Harmonisation of Technical Requirements for Pharmaceuticals for Human Use. ICH GCP E6(R2) Guideline for Good Clinical Practice. 2016."},{"key":"bibr88-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1177\/0962280215588241"},{"key":"bibr89-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2019.01.007"},{"key":"bibr90-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1191\/1740774504cn032oa"},{"key":"bibr91-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-9-51"},{"key":"bibr92-15347354241252698","volume":"2016","author":"Cramer H","journal-title":"Evid Based Complement Alternat Med"},{"key":"bibr93-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61344-5"},{"key":"bibr94-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1002\/1098-240X(200008)23:4<334::AID-NUR9>3.0.CO;2-G"},{"key":"bibr95-15347354241252698","first-page":"108","volume":"17","author":"Zheng G","year":"2017","journal-title":"Journal of the Australian - Traditional Medicine Society"},{"key":"bibr96-15347354241252698","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2019.0455"},{"key":"bibr97-15347354241252698","volume-title":"Guolin New Qigong Practice Manual","author":"Yu DY.","year":"2021"}],"container-title":["Integrative Cancer Therapies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15347354241252698","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15347354241252698","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15347354241252698","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:17:22Z","timestamp":1777454242000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15347354241252698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":97,"alternative-id":["10.1177\/15347354241252698"],"URL":"https:\/\/doi.org\/10.1177\/15347354241252698","relation":{},"ISSN":["1534-7354","1552-695X"],"issn-type":[{"value":"1534-7354","type":"print"},{"value":"1552-695X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"15347354241252698"}}