{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T22:31:19Z","timestamp":1792881079456,"version":"4.5.0"},"reference-count":23,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K09589"],"award-info":[{"award-number":["20K09589"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Integr Cancer Ther"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Development of chemotherapy-induced peripheral neuropathy (CIPN) poses significant challenges in cancer treatment, often leading to dose reductions or treatment discontinuation. Goshajinkigan (GJG), a traditional Japanese medicine, has shown promise for alleviating CIPN symptoms. This multicenter, randomized controlled trial aimed to prospectively examine the efficacy of GJG in preventing paclitaxel-induced peripheral neuropathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study enrolled 55 patients with ovarian cancer undergoing first-line chemotherapy using paclitaxel and carboplatin. The participants were randomized into Groups A (GJG initiation after onset of grade 2 neuropathy) and B (prophylactic administration of GJG from 1\u2009week before chemotherapy). The primary endpoints were the proportion with a maximum sensory neuropathy grade and visual analog scale (VAS) scores. The secondary endpoints were the rate of chemotherapy completion and paclitaxel dose reduction due to neurotoxicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Prophylactic GJG administration (Group B) resulted in significant benefits. While both groups had a similar incidence of grade 2 sensory neuropathy, all patients in Group B with grade 2 neuropathy completed treatment without requiring additional analgesics. Group B exhibited lower VAS scores by the end of the study, reduced reliance on adjuvant analgesics (27.3% vs 66.7% in Group A), and significantly less frequent persistent CIPN 6 months post-chemotherapy (18.2% vs 55.6% in Group A). No differences were observed in the chemotherapy completion rates or CIPN-related changes between the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>GJG, when administered prophylactically, showed potential for mitigating CIPN symptoms during paclitaxel chemotherapy. While promising, further research with placebo controls and objective measures is essential to comprehensively validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15347354241278635","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T21:19:18Z","timestamp":1726262358000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Effectiveness of the Traditional Japanese Medicine Goshajinkigan in Preventing Paclitaxel-Induced Peripheral Neuropathy: A Multicenter Randomized Comparative Trial"],"prefix":"10.1177","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0560-3923","authenticated-orcid":false,"given":"Yukiko","family":"Matsumura","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Futagami","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tokyo Medical University Ibaraki Medical Center, Ami, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsukasa","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Yahaba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Soeda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidemichi","family":"Watari","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Terada","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine, Akita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Tokunaga","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tohoku University Graduate Schoool of Medicine, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Nagase","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, Yamagata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology, Tohoku Medical and Pharmaceutical University Faculty of Medicine, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Kaiho","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Miyagi Cancer Center, Natori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihito","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,10]]},"reference":[{"key":"bibr1-15347354241278635","doi-asserted-by":"publisher","DOI":"10.1007\/S12094-010-0474-z"},{"key":"bibr2-15347354241278635","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-021-06196-8"},{"key":"bibr3-15347354241278635","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X15666170915143217"},{"key":"bibr4-15347354241278635","doi-asserted-by":"publisher","DOI":"10.2217\/pmt-2018-0020"},{"key":"bibr5-15347354241278635","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2019.102831"},{"key":"bibr6-15347354241278635","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2011.10.019"},{"key":"bibr7-15347354241278635","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-014-2255-7"},{"key":"bibr8-15347354241278635","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1080888"},{"key":"bibr9-15347354241278635","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.09.020"},{"key":"bibr10-15347354241278635","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/128726"},{"key":"bibr11-15347354241278635","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.13244fp"},{"key":"bibr12-15347354241278635","unstructured":"Kitamura R, Andoh T, Fushimi H, et al. 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