{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:19:14Z","timestamp":1777695554968,"version":"3.51.4"},"reference-count":70,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Healing Touch Worldwide Foundation"},{"name":"NIH","award":["#P20AT75601"],"award-info":[{"award-number":["#P20AT75601"]}]},{"name":"NIH","award":["#R21AT0095801"],"award-info":[{"award-number":["#R21AT0095801"]}]},{"name":"NIH","award":["#UL1RR024979"],"award-info":[{"award-number":["#UL1RR024979"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Integr Cancer Ther"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Cancer treatment with chemotherapy frequently leads to side effects such as fatigue, pain, nausea, and anxiety. Healing Touch is a non-invasive complementary therapy often used by cancer patients to address side effects of treatment. To better inform the use of complementary therapies, there is a need to understand the biological mechanisms underlying the effects of such treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study included 44 patients with cervical cancer undergoing chemoradiation randomized into a Healing Touch (HT), a relaxation training (RT) and a usual care (UC) group. An exploratory metabolomics analysis was conducted on plasma samples taken at baseline, 4, and 6\u2009weeks of ongoing treatment (4 sessions per week).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A multivariate data analysis revealed no significant separation in metabolites between the 3 groups. Univariate data analysis revealed changes in metabolites between baseline and week 6 within each group. The main findings were lower levels of acylcarnitines, bile acids and proline in the HT group, higher levels of fatty acids in the HT and RT groups, and lower levels of kynurenine and quinolate in the UC group. The network of correlations between metabolites shows clear differences in correlations between steroids, fatty acids, sphyngomyelins, amino acids, and \u03b3 glutamyl peptides between the 3 groups, suggesting a more flexible and resilient metabolism in the HT and RT groups compared with UC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This first exploratory study investigating metabolic effects of Healing Touch in cancer patients indicated suggestive differences in metabolic signatures which need further investigation in a larger study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15347354251367793","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T05:43:39Z","timestamp":1757051019000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Metabolic Effects of Healing Touch During Cervical Cancer Treatment: An Exploratory Analysis"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2225-0337","authenticated-orcid":false,"given":"Herman A.","family":"van Wietmarschen","sequence":"first","affiliation":[{"name":"Louis Bolk Institute, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estela","family":"Area-Gomez","sequence":"additional","affiliation":[{"name":"University of Madrid, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Picard","sequence":"additional","affiliation":[{"name":"Columbia University, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Goodheart","sequence":"additional","affiliation":[{"name":"University of Iowa, Iowa, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil K.","family":"Sood","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3793-5881","authenticated-orcid":false,"given":"Susan K.","family":"Lutgendorf","sequence":"additional","affiliation":[{"name":"University of Iowa, Iowa, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-11-200006060-00009"},{"issue":"3","key":"e_1_3_3_3_2","first-page":"34","article-title":"Healing touch and quality of life in women receiving radiation treatment for cancer: a randomized controlled trial","volume":"10","author":"Cook CA","year":"2004","unstructured":"Cook CA, Guerrerio JF, Slater VE. 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