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Traditional herbal medicine (THM), particularly Fuzheng-Based Qi and Yin Therapy (FBQYT), has emerged as a promising adjuvant therapy to mitigate these effects and enhance immune response. This meta-analysis evaluates the efficacy and safety of THM as an adjunct to palliative chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A systematic search was conducted in PubMed, EMBASE, ScienceON, RISS, KMBASE, OASIS, Cochrane Library, KISS, CNKI, and CiNii up to April 2025. Outcomes included tumor response, quality of life (QoL), adverse drug reactions (ADRs), and tumor markers. Eighty randomized controlled trials (RCTs) involving stage III\/IV lung cancer patients were analyzed using Review Manager Software 5.4.1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Combining chemotherapy with THM significantly improved the objective response rate (ORR, RR 1.41) and disease control rate (DCR, RR 1.20). It also enhanced quality of life, increasing Karnofsky Performance Status (KPS) score (MD 8.53) and KPS improvement (RR 1.51), alongside improvements in Quality of Life Questionnaire-Core 30 (QLQ-C30) total score (MD 13.05). Tumor markers and most ADRs were reduced, except for neutropenia, liver injury, and diarrhea (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&gt;\u2009.05). Survival rates, progression-free survival (PFS), and median survival time (MST) were higher in the THM group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Integrating THM with palliative chemotherapy enhances tumor response, QoL, and survival rates while reducing adverse effects. Further rigorous RCTs are needed to confirm these findings and address methodological limitations.<\/jats:p>\n                    <jats:p>Registration: PROSPERO CRD 42024523418.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15347354251373045","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T06:56:34Z","timestamp":1760684194000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Efficacy of Herbal Medicine Therapy Combined With Palliative Chemotherapy in Unresectable Advanced NSCLC: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0651-9628","authenticated-orcid":false,"given":"Keon-Jun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Korean Internal Medicine, Korean Medicine Hospital, Pusan National University, Yangsan, Republic of Korea"},{"name":"Department of Korean Medicine, Graduate School, Daejeon University, Daejeon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Ha","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Korean Internal Medicine, School of Korean Medicine, Pusan National University, Yangsan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2144-2284","authenticated-orcid":false,"given":"Dong-Hyeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Korean Internal Medicine, Korean Medicine Hospital, Pusan National University, Yangsan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-Sun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Korean Internal Medicine, School of Korean Medicine, Pusan National University, Yangsan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye-Jin","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Korean Internal Medicine, School of Korean Medicine, Pusan National University, Yangsan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Korean Internal Medicine, School of Korean Medicine, Pusan National University, Yangsan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwa-Seung","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Korean Medicine, Graduate School, Daejeon University, Daejeon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8829-1716","authenticated-orcid":false,"given":"So-Jung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Korean Internal Medicine, Korean Medicine Hospital, Pusan National University, Yangsan, Republic of Korea"},{"name":"Department of Korean Internal Medicine, School of Korean Medicine, Pusan National University, Yangsan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2019.01.013"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000032899"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2007.06.018"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.0393"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.063"},{"issue":"1","key":"e_1_3_3_8_2","first-page":"12","article-title":"Multi-centered randomized controlled study of Chinese medicine integrated with chemotherapy for stage IV non-small cell lung cancer","volume":"41","author":"Song LJ","year":"2022","unstructured":"Song LJ, Ma XJ, Zheng JB, et al Multi-centered randomized controlled study of Chinese medicine integrated with chemotherapy for stage IV non-small cell lung cancer. 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