{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:20:04Z","timestamp":1777695604642,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Integr Cancer Ther"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Paclitaxel-induced peripheral neuropathy (PIPN) is a dose-limiting adverse effect during paclitaxel therapy, with no effective treatment and often incomplete recovery. This study assessed the effects of exercise on PIPN severity in newly diagnosed advanced breast cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The ExPIN Trial is an ongoing randomized clinical trial. This interim analysis, conducted between November 2022 and December 2023, included adult patients with locally advanced, non-metastatic breast cancer. Participants were randomized into interventional and control groups for 0 to 12\u2009weeks. The primary outcome was nerve conduction studies. Secondary outcomes included balance scores, taxane-induced toxicity-related quality-of-life scores, emotional functioning, physical functioning, and functional impairments assessed at baseline, after chemotherapy, and at the first follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Seventy patients were randomized. The mean (SD) age was 49.46 (9.52) years in the interventional group and 49.09 (8.10) years in the control group. At the completion of paclitaxel therapy, the amplitudes of the ulnar nerve (estimate: 1.98,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.007), common peroneal nerve (estimate: 1.88,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.003), and sural nerve (estimate: 6.20,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001) were significantly higher in the interventional group. On the EORTC scale (lower scores indicate better quality of life), sensory and motor scores significantly decreased in the interventional group by the end of therapy (\u22125.46 and \u22123.82,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001), indicating improvement. These improvements were sustained at follow-up (\u22121.99,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.001, and \u22124.20,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Exercise intervention during paclitaxel therapy significantly reduced PIPN severity and improved quality of life. Findings are preliminary and warrant further confirmation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15347354251398002","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T07:21:21Z","timestamp":1766128881000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Exercise on Severity of Paclitaxel-Induced Peripheral Neuropathy and Improving Quality of Life in Women with Non-metastatic Breast Cancer: Results of an Interim Analysis from an Ongoing Randomized Clinical Trial (ExPIN Trial)"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1940-4493","authenticated-orcid":false,"given":"Mangaiyarkarasi","family":"Sekaran","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3520-4420","authenticated-orcid":false,"given":"Ananth","family":"Pai","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1999-0206","authenticated-orcid":false,"given":"Arvind N.","family":"Prabhu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4081-1372","authenticated-orcid":false,"given":"Vasudeva","family":"Bhat K","sequence":"additional","affiliation":[{"name":"Department of Paediatric Oncology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5392-6825","authenticated-orcid":false,"given":"Chethan","family":"Channaveera","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8621-6106","authenticated-orcid":false,"given":"Jeffrey","family":"Pradeep Raj","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3319-9661","authenticated-orcid":false,"given":"Vijetha Shenoy","family":"Belle","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2003-426X","authenticated-orcid":false,"given":"Sharada","family":"Mailankody","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4906-3972","authenticated-orcid":false,"given":"Karthik S.","family":"Udupa","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-010-1278-0"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djx162"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0707056"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.0308"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-0772-03"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2009.10.006"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.6699"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-04680-w"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5522-7"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/82.4.383"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40798-024-00729-1"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physio.2016.11.001"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/15347354251313534"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002151"},{"key":"e_1_3_3_16_2","unstructured":"National Cancer Institute. Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. U.S. Department of Health and Human Services; 2017. Accessed December 4 2024. https:\/\/ctep.cancer.gov\/protocoldevelopment\/electronic_applications\/ctc.htm"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbmt.2023.09.001"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11578"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2022.23.5.1547"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/toxics3020152"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21204"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-017-4013-0"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-023-01450-w"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2014.03.007"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1188\/12.ONF.E416-E424"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14051224"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells14070487"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1505879"},{"issue":"1","key":"e_1_3_3_29_2","first-page":"15","article-title":"Prevention and treatment of chemotherapy-induced peripheral neuropathy (CIPN) with non-pharmacological interventions: clinical recommendations from a systematic scoping review and an expert consensus process","volume":"11","author":"Klafke N","year":"2023","unstructured":"Klafke N, Bossert J, Kr\u00f6ger B, et al Prevention and treatment of chemotherapy-induced peripheral neuropathy (CIPN) with non-pharmacological interventions: clinical recommendations from a systematic scoping review and an expert consensus process. Med Sci. 2023;11(1):15.","journal-title":"Med Sci"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2010.0681"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1460992"},{"issue":"10","key":"e_1_3_3_32_2","first-page":"677","article-title":"Update in: Pilot trial testing the effects of exercise on chemotherapy-induced peripheral neurotoxicity (CIPN) and the interoceptive brain system","volume":"32","author":"Kleckner IR","year":"2024","unstructured":"Kleckner IR, Manuweera T, Lin PJ, et al Update in: Pilot trial testing the effects of exercise on chemotherapy-induced peripheral neurotoxicity (CIPN) and the interoceptive brain system. Res Sq [Preprint]. 2024:rs.3.rs-4022351. Support Care Cancer. 2024;32(10):677.","journal-title":"Support Care Cancer"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4668-z"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.4103\/crst.crst_170_24"}],"container-title":["Integrative Cancer Therapies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15347354251398002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15347354251398002","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15347354251398002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:17:58Z","timestamp":1777454278000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15347354251398002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":33,"alternative-id":["10.1177\/15347354251398002"],"URL":"https:\/\/doi.org\/10.1177\/15347354251398002","relation":{},"ISSN":["1534-7354","1552-695X"],"issn-type":[{"value":"1534-7354","type":"print"},{"value":"1552-695X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"article-number":"15347354251398002"}}