{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:20:34Z","timestamp":1777695634022,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100016624","name":"Applied Science Private University","doi-asserted-by":"publisher","award":["DRGS-2024-1"],"award-info":[{"award-number":["DRGS-2024-1"]}],"id":[{"id":"10.13039\/100016624","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Integr Cancer Ther"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Prangos ferulacea<\/jats:italic>\n                    is a widely recognized and valuable medicinal herb known for its diverse biological characteristics. Our study was conducted to evaluate the anticancer and immunomodulatory effects of\n                    <jats:italic toggle=\"yes\">P. ferulacea<\/jats:italic>\n                    . Ethyl acetate, methanol, and aqueous extracts were prepared from\n                    <jats:italic toggle=\"yes\">P. ferulacea<\/jats:italic>\n                    , and the MTT assay was used to measure antiproliferation activity against 5 cancer cell lines (MDA-MB231, T47-D, HeLa, EMT6\/P, and Vero). The 3 extracts underwent a qualitative LC\/MS spectrometry analysis to determine each extract\u2019s composition. The MTT test was used to measure the proliferation of lymphocytes. Extracts were evaluated for their effects on macrophages phagocytic activity and pinocytosis function using the nitro blue tetrazolium assay and the neutral red method, respectively. The impact of ethyl acetate and methanol was assessed in mice inoculated with EMT6\/P using the in vivo model, and the tumor size was measured. Results showed that ethyl acetate and methanol extracts had the highest activity against T47-D with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 0.019\u2009mg\/ml. The ethyl acetate extract exhibited moderate effectiveness against the following cell lines: MDA-MB-231 and EMT6\/P with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 0.104 and 0.255\u2009mg\/ml, respectively. Meanwhile, methanol extract showed activity against MDA-MB231 and EMT6\/P cell lines and had IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 0.214 and 0.31\u2009mg\/ml, respectively. Regarding immunomodulatory assays, the methanol extract, followed by the ethyl acetate extract, significantly increases lymphocyte proliferation and macrophage phagocytosis activity. Aqueous extracts increase the activity of pinocytosis. Both ethyl acetate and methanol extracts reduced tumor size by 61.46% and 34.47%, respectively. They also decreased the average weight of the tumor cells in the in vivo model. The results of\n                    <jats:italic toggle=\"yes\">P. ferulacea<\/jats:italic>\n                    have valuable activity against cancer cells and stimulate the immune system. However, further molecular investigations are required to understand the mechanism of action of\n                    <jats:italic toggle=\"yes\">P. ferulacea<\/jats:italic>\n                    activity.\n                  <\/jats:p>","DOI":"10.1177\/15347354251413219","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T14:08:57Z","timestamp":1773238137000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti-Cancer and Immunomodulatory Activities of\n                    <i>Prangos ferulacea<\/i>\n                    (L.) Lindl. (APIACEAE) Extracts: An In Vitro and In Vivo Study"],"prefix":"10.1177","volume":"25","author":[{"given":"Shefaa M.","family":"Alzoubi","sequence":"first","affiliation":[{"name":"Applied Science Private University, Amman, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moudi M.","family":"Alasmari","sequence":"additional","affiliation":[{"name":"King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Jeddah, Saudi Arabia"},{"name":"King Abdullah International Medical Research Centre (KAIMRC), Jeddah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saman A.","family":"Ahmad","sequence":"additional","affiliation":[{"name":"University of Sulaimani, Iraq"},{"name":"The American University of Iraq, Sulaimani, Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heba K.","family":"Alshaeri","sequence":"additional","affiliation":[{"name":"King Abdulaziz University, Rabigh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ala\u2019 M.","family":"Abuh-Odeh","sequence":"additional","affiliation":[{"name":"Applied Science Private University, Amman, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1942-8982","authenticated-orcid":false,"given":"Wamidh H.","family":"Talib","sequence":"additional","affiliation":[{"name":"Applied Science Private University, Amman, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(23)00406-0"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2021.2433"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-024-12715-7"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_201806_15270"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2021-0463"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2020.102016"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-019-0108-1"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph14020157"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113384"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/plants13010042"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1597602"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116531"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12020384"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.34172\/ijep.2021.11"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115570"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.3224"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.22034\/jmpb.2024.364496.1644"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-0873-8622"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-40535-5"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.31925\/farmacia.2024.1.18"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.829101"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/plants10040617"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3897\/pharmacia.71.e111517"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/plants13010035"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.3897\/pharmacia.68.e71695"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/00236772251332722"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.05.050"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2012.13.8.3989"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.2710"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph15121502"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph15121504"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.29252\/jmj.9.4.1"},{"issue":"7","key":"e_1_3_3_34_2","first-page":"917","article-title":"Acute toxicity studies and determination of median lethal dose","volume":"93","author":"Akhila JS","year":"2007","unstructured":"Akhila JS, Shyamjith D, Alwar MC. 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