{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:20:38Z","timestamp":1777695638873,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100008891","name":"loma linda university","doi-asserted-by":"publisher","award":["2160303-01"],"award-info":[{"award-number":["2160303-01"]}],"id":[{"id":"10.13039\/100008891","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Integr Cancer Ther"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>\n                    This study compared Intraneural Facilitation (INF\n                    <jats:sup>\u00ae<\/jats:sup>\n                    ) therapy and standard physical therapy (PT) in preventing chemotherapy-induced peripheral neuropathy (CIPN) in women with newly diagnosed breast and gynecologic cancer. Thirty-eight women undergoing platinum and\/or taxane-based chemotherapy, without prior peripheral neuropathy, were randomized into INF\n                    <jats:sup>\u00ae<\/jats:sup>\n                    therapy (n\u2009=\u200920) and PT (n\u2009=\u200918). Treatments lasted 45\u2009minutes, twice weekly, for 6\u2009weeks. Neuropathy severity was evaluated using the Pain Quality Assessment Scale. Assessments were at baseline, 3\u2009weeks, 6\u2009weeks, and 3\u2009months post-intervention. Acceptability, burden, and satisfaction were evaluated after 6\u2009weeks. Among 38 patients, 12 (32%) experienced CIPN, with mean pain scores remaining mild (\u22643) and no pharmacotherapy required until week 6. No adverse events were reported from the interventions. The INF\n                    <jats:sup>\u00ae<\/jats:sup>\n                    therapy arm showed significant changes in numbness (\n                    <jats:italic toggle=\"yes\">F<\/jats:italic>\n                    \u2009=\u20096.030,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.001, partial \u03b7\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.262) after week 6, while the PT arm showed significant changes in numbness (\n                    <jats:italic toggle=\"yes\">Z<\/jats:italic>\n                    \u2009=\u2009\u22122.39,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.017), tingling (\n                    <jats:italic toggle=\"yes\">Z<\/jats:italic>\n                    \u2009=\u2009\u22122.84,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.004), cramping (\n                    <jats:italic toggle=\"yes\">Z<\/jats:italic>\n                    \u2009=\u2009\u22122.120,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.034), surface pain (\n                    <jats:italic toggle=\"yes\">Z<\/jats:italic>\n                    \u2009=\u2009\u22122.75,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.006), and deep pain (\n                    <jats:italic toggle=\"yes\">Z<\/jats:italic>\n                    \u2009=\u2009\u22121.99,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.046) between weeks 3 and 6. Nearly 80% of patients completed chemotherapy cycles with an average relative dose intensity of 90.4% (INF\n                    <jats:sup>\u00ae<\/jats:sup>\n                    therapy: 87.73% vs PT: 73.44%). Ninety-four percent of patients were satisfied with their care, accepted the treatments, and perceived them as a low burden. The results demonstrated that INF\n                    <jats:sup>\u00ae<\/jats:sup>\n                    therapy and PT are feasible options for CIPN, improving treatment adherence, outcomes, and quality of life for women with newly diagnosed breast and gynecological cancers.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration<\/jats:bold>\n                    - The study was pre-registered on ClinicalTrials.gov (NCT03272919). August 8, 2017.\n                  <\/jats:p>","DOI":"10.1177\/15347354251413222","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T04:53:39Z","timestamp":1773723219000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Approach of Intraneural Facilitation Versus Standard Physical Therapy for the Prevention of Chemotherapy-Induced Peripheral Neuropathy: A Randomized Controlled Trial"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6889-7668","authenticated-orcid":false,"given":"Jamie","family":"Hankins","sequence":"first","affiliation":[{"name":"Loma Linda University Health, Loma Linda, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6539-4723","authenticated-orcid":false,"given":"Mark","family":"Bussell","sequence":"additional","affiliation":[{"name":"Loma Linda University Health, Loma Linda, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lida","family":"Gharibvand","sequence":"additional","affiliation":[{"name":"Loma Linda University School of Allied Health Professions, Loma Linda, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Jin","family":"Jeon","sequence":"additional","affiliation":[{"name":"Loma Linda University School of Medicine, Loma Linda, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dani Ran","family":"Castillo","sequence":"additional","affiliation":[{"name":"Loma Linda University School of Medicine, Loma Linda, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"D\u2019Errico","sequence":"additional","affiliation":[{"name":"Loma Linda University School of Nursing, Loma Linda, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7586-6920","authenticated-orcid":false,"given":"Gayathri","family":"Nagaraj","sequence":"additional","affiliation":[{"name":"Loma Linda University School of Medicine, Loma Linda, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40487-021-00168-y"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12337"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112671"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2019.102831"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-021-05576-6"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00174"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.11.011"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-021-06042-x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2021.09.004"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.71.3552"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-022-01182-3"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2022.102134"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2019.05.013"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31248"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-017-2031-8"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.21625.1"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2016.00372"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.243699"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2015.12.026"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.2018.32.1_supplement.853.19"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e31816b1058"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-013-2582-2"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.10.030"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000005101"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-023-01107-4"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-023-01450-w"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001540"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-017-4013-0"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djx140"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.1081"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.12093"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2012.000863"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/2193-1801-3-366"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-021-00997-w"}],"container-title":["Integrative 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