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While surgery and chemotherapy are primary treatments, their side effects\u2014such as nausea, vomiting, and immunosuppression\u2014significantly impact quality of life (QoL). Acupuncture and moxibustion, commonly used in Traditional Asian Medicine (TAM), are proposed to alleviate these effects, though their efficacy in NSCLC remains uncertain. This systematic review and meta-analysis evaluated their impact on QoL, chemotherapy-induced nausea and vomiting (CINV), and immune function in NSCLC patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Nine databases (PubMed, Embase, Cochrane Library, CNKI, OASIS, ScienceON, KISS, KMBASE, and RISS) were searched for randomized controlled trials (RCTs) published until April 2025. RCTs comparing acupuncture or moxibustion with standard care in NSCLC patients were included. Primary outcomes were QoL (QLQ-C30, KPS); secondary outcomes included CINV and immune markers (CD3, CD4, CD8, CD4\/CD8 ratio, TNF-\u03b1). Data were analyzed using Review Manager 5.4, and risk of bias was assessed using the Cochrane RoB tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Thirty-nine RCTs (N\u2009=\u20093610) were included. Acupuncture and moxibustion significantly improved QoL (QLQ-C30 MD\u2009=\u200912.39; KPS MD\u2009=\u20098.22; both\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.00001), reduced CINV incidence (RR\u2009=\u20090.32,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.00001), and enhanced symptom relief (RR\u2009=\u20091.16,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.00001). Immune function markers, including CD3 (MD\u2009=\u20097.20,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.0002), CD4 (MD\u2009=\u20094.89,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.0003), and the CD4\/CD8 ratio (MD\u2009=\u20090.22,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.00001), were significantly increased, while TNF-\u03b1 levels decreased (MD\u2009=\u2009\u221211.05,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Acupuncture and moxibustion improve QoL, reduce CINV, and modulate immune function in NSCLC, supporting their complementary role.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15347354261419716","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T11:28:42Z","timestamp":1771500522000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness of Acupuncture and Moxibustion for Non\u2013Small Cell Lung Cancer (NSCLC) Patients Undergoing Standard Treatment: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2144-2284","authenticated-orcid":false,"given":"Dong-Hyeon","family":"Kim","sequence":"first","affiliation":[{"name":"Korean Medicine Hospital, Pusan National University, Yangsan,Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-Sun","family":"Park","sequence":"additional","affiliation":[{"name":"School of Korean Medicine, Pusan National University, Yangsan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0651-9628","authenticated-orcid":false,"given":"Keon-Jun","family":"Lee","sequence":"additional","affiliation":[{"name":"Graduate School, Daejeon University, Daejeon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Ha","family":"Kwon","sequence":"additional","affiliation":[{"name":"School of Korean Medicine, Pusan National University, Yangsan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye-Jin","family":"Jin","sequence":"additional","affiliation":[{"name":"School of Korean Medicine, Pusan National University, Yangsan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So-Jung","family":"Park","sequence":"additional","affiliation":[{"name":"Korean Medicine Hospital, Pusan National University, Yangsan,Republic of Korea"},{"name":"School of Korean Medicine, Pusan National University, Yangsan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"International Agency for Research on Cancer. 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