{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T09:00:55Z","timestamp":1780736455754,"version":"3.54.1"},"reference-count":36,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074088 and 81573728"],"award-info":[{"award-number":["82074088 and 81573728"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Academic Promotion Program of Shandong First Medical University","award":["2019QL007"],"award-info":[{"award-number":["2019QL007"]}]},{"name":"Key R&D Program of Shandong Province, China","award":["2022CXGC020514"],"award-info":[{"award-number":["2022CXGC020514"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Integr Cancer Ther"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Radiation-induced quantitative deficiency of T helper 1 (Th1) cells accelerates lung tumor development. Here, we evaluated IL-7R\u2013STAT5 signaling in Th1 recovery after irradiation and examined how catalpol contributes to Th1 reconstitution by targeting this signaling axis in mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      The recovery characteristics of irradiated Th1 cells, compared with other IFN-\u03b3-producing (IFN-\u03b3\n                      <jats:sup>+<\/jats:sup>\n                      ) cells, were analyzed in local radiotherapy (LRT) mice challenged with lung melanoma and single low-dose total body irradiation (SLTBI) mice without tumor. IL-7R\u2013STAT5 signaling of Th1 from LRT mice, treated with or without catalpol, was evaluated using flow cytometry and RT-qPCR. The role of IL-7\u2013IL-7R\u2013STAT5 signaling in irradiated Th1 cells was further confirmed in irradiated EL4 cells following administration of IL-7 or catalpol.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Th1 subsets showed delayed recovery in both LRT and SLTBI mice compared with other IFN-\u03b3\n                      <jats:sup>+<\/jats:sup>\n                      cells, and irradiated Th1 cells exhibited decreased activation of IL-7R\u2013STAT5 signaling. Quantitative reduction of Th1 cells increased lung metastasis of B16 melanoma in irradiated mice. Irradiated EL4 cells also displayed decreased IL-7R\u2013STAT5 signaling and reduced IFN-\u03b3 production in vitro. Treatment with catalpol could restore IL-7R\u2013STAT5 signaling and promote Th1 recovery following irradiation both in vivo and in vitro. Catalpol-mediated restoration of IL-7R\u2013STAT5 signaling in Th1 provided superior protection against B16 melanoma metastasis to the lung.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>IL-7R\u2013STAT5 signaling is required for Th1 recovery after irradiation. Catalpol effectively promotes Th1 cell reconstitution and decreases B16 melanoma metastasis to the lung by enhancing IL-7R\u2013STAT5 signaling. These findings provide new strategies for improving radiotherapy and immunotherapy outcomes in cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15347354261453338","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:59:25Z","timestamp":1780552765000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Catalpol Reactivates IL-7R\u2013STAT5 Signaling and Reverses Radiation-Induced T Helper 1 Cells Deficiency to Limit Melanoma Metastasis to Lung"],"prefix":"10.1177","volume":"25","author":[{"given":"Shan","family":"Zhang","sequence":"first","affiliation":[{"name":"Chongqing University (Shapingba District People\u2019s Hospital of Chongqing), China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tianjin Rehabilitation and Convalescence Center, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyan","family":"Ma","sequence":"additional","affiliation":[{"name":"Second Hospital Affiliated to Tianjin Medical University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Huang","sequence":"additional","affiliation":[{"name":"Chengdu University of TCM, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6233-7069","authenticated-orcid":false,"given":"Rongrui","family":"Tang","sequence":"additional","affiliation":[{"name":"Chongqing University (Shapingba District People\u2019s Hospital of Chongqing), China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlian","family":"Hao","sequence":"additional","affiliation":[{"name":"Tianjin Rehabilitation and Convalescence Center, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-025-02198-8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2022.11.007"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00568-1"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21689"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-00457-z"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2021.04.009"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2018.06.001"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1667\/RR13550.1"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2021.02.011"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2021.05.014"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.09.014"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.02.041"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-019-0899-2"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.09.024"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.01.021"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom11020323"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c07286"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00690"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.10.054"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-025-01382-4"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14174178"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2022.06.092"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2020.01.030"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2016.06.003"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.744107"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2007.09.015"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2015.08.034"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1379376"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26188788"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-042718-041447"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2023"},{"key":"e_1_3_2_33_2","volume-title":"Molecular Mechanisms of Cytokine-Induced Modulation of CD8+ T Cell Antigen Receptor Signaling","author":"Quenum AJI","year":"2024","unstructured":"Quenum AJI. 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