{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T17:16:09Z","timestamp":1788023769057,"version":"build-2784847793"},"reference-count":42,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Ministry of Health & Welfare, Republic of Korea","award":["RS-2023-CC138341"],"award-info":[{"award-number":["RS-2023-CC138341"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Integr Cancer Ther"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Lentinula edodes<\/jats:italic>\n                    extracts are used by cancer patients as alternative or complementary therapies; however, no systematic review has evaluated their actual benefits. We searched several databases (Medline, Embase, Cochrane Library, CINAHL, AMED, and KoreanMed) and included studies comparing groups receiving\n                    <jats:italic toggle=\"yes\">L. edodes<\/jats:italic>\n                    extracts alongside standard treatment with those receiving standard treatment alone. A total of 22 trials involving 1,723 cancer patients were included. Of these, 13 were randomized controlled trials (RCTs) and nine were controlled non-randomized trials (NRTs). In the analysis of the 13 RCTs, the\n                    <jats:italic toggle=\"yes\">L. edodes<\/jats:italic>\n                    group showed a better response rate than the control group (odds ratio, 1.45; 95% confidence interval [CI], 1.01\u20132.07;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.04). However, there was no significant difference in overall survival between the two groups (hazards ratio, 0.66; 95% CI, 0.34\u20131.28;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.22). There was also no difference in the incidence of hematological or non-hematological adverse events (AEs) between the groups. Similarly, no significant difference in overall quality of life (QoL) was observed (standard mean difference, 0.23; 95% CI [-0.16, 0.62];\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.25). In the nine NRTs, the\n                    <jats:italic toggle=\"yes\">L. edodes<\/jats:italic>\n                    group demonstrated favorable outcomes in tumor response and QoL (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.05). This review found that\n                    <jats:italic toggle=\"yes\">L. edodes<\/jats:italic>\n                    extracts were associated with improved tumor response. However, these results have many limitations and do not translate into improved survival. Additionally, no differences were found in AEs or QoL. Overall, the evidence does not support clear recommendations, and more high-quality, well-designed randomized trials are needed.\n                  <\/jats:p>","DOI":"10.1177\/15347354261483632","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:30:16Z","timestamp":1787787016000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Lentinula edodes<\/i>\n                    in Cancer Treatment: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6294-9591","authenticated-orcid":false,"given":"Byeong Seok","family":"Sohn","sequence":"first","affiliation":[{"name":"Sanggye Paik Hospital"},{"name":"Inje University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Sil","family":"Choi","sequence":"additional","affiliation":[{"name":"Seoul Metropolitan Government Seoul National University Boramae Medical Center"},{"name":"Seoul National University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Kangdong Sacred Heart Hospital"},{"name":"Hallym University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Il","family":"Kim","sequence":"additional","affiliation":[{"name":"Chungnam National University Sejong Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Hoon","family":"Maeng","sequence":"additional","affiliation":[{"name":"Kyung Hee University Hospital"},{"name":"Kyung Hee University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9779-9060","authenticated-orcid":false,"given":"Youngduk","family":"Seo","sequence":"additional","affiliation":[{"name":"Chungnam National University Sejong Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn Ju","family":"Lee","sequence":"additional","affiliation":[{"name":"Chungnam National University Sejong Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wonyoung","family":"Jung","sequence":"additional","affiliation":[{"name":"Kangdong Sacred Heart Hospital"},{"name":"Hallym University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok Jae","family":"Huh","sequence":"additional","affiliation":[{"name":"Dong-A University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Young","family":"Rha","sequence":"additional","affiliation":[{"name":"Yonsei Cancer Center"},{"name":"Yonsei University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Hye","family":"Kwon","sequence":"additional","affiliation":[{"name":"Chung-Ang University College of Medicine"},{"name":"Chung-Ang University Gwang Myeong Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2005.04.126"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/222687a0"},{"issue":"4","key":"e_1_3_6_5_2","first-page":"551","article-title":"Induction of cytotoxic peritoneal exudate cells by T-cell immune adjuvants of the beta(1 leads to 3) glucan-type lentinan and its analogues","volume":"39","author":"Hamuro J","year":"1980","unstructured":"Hamuro J, R\u00f6llinghoff M, Wagner H. 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