{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T01:01:10Z","timestamp":1793840470390,"version":"4.6.1"},"reference-count":29,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Imaging"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n                    Immunologic thrombocytopenic purpura (ITP) is a condition that affects four to 18 per 100\u2005000 children every year. In most cases, spontaneous remission occurs, but splenectomy may be proposed. Exploring the site of platelet sequestration can help to better predict potential poor responders to splenectomy, but\n                    <jats:sup>111<\/jats:sup>\n                    In-radiolabeled platelet scintigraphy (IPS) can be difficult to perform in children with very few platelets. A 12-year-old boy suffering from refractory ITP was referred for evaluation of platelet survival and sequestration and consideration of splenectomy. His platelet count consistently remained below 10\u2005000\/mm\n                    <jats:sup>3<\/jats:sup>\n                    . An exceptional procedure was set up to use homologous platelets to perform the IPS. Splenectomy was ruled out based on the results of\n                    <jats:sup>111<\/jats:sup>\n                    In-radiolabeled homologous platelet scintigraphy. The attending pediatrician intensified medical treatments, resulting in a significant improvement in platelet count. This increase in platelet levels allowed for\n                    <jats:sup>111<\/jats:sup>\n                    In-radiolabeled autologous platelet scintigraphy, which confirmed the absence of splenic sequestration. This allowed us to reject splenectomy in this child. Homologous IPS could help clinicians to choose splenectomy as a treatment option for ITP in children with a very low platelet count, and its use should be promoted after failed thrombopoietin receptor agonist (TPO-RA) treatment. More systematic studies are needed to confirm the predictive response to splenectomy of homologous IPS.\n                  <\/jats:p>","DOI":"10.1177\/15353508241293961","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T01:04:49Z","timestamp":1730941489000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Homologous\n                    <sup>111<\/sup>\n                    In-Radiolabeled Platelet Survival and Sequestration Exploration for Refractory Immunologic Thrombocytopenic purpura in Children: A Strategy to Avoid Unnecessary Splenectomy"],"prefix":"10.1177","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1046-3200","authenticated-orcid":false,"given":"Julien","family":"Dubois","sequence":"first","affiliation":[{"name":"Radiopharmacy Department, Montpellier University Hospital, University of Montpellier, Montpellier, France"},{"name":"Cancer Research Institute of Montpellier (IRCM), INSERM U1194, University of Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florentin","family":"Kucharczak","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, Montpellier University Hospital, University of Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9a","family":"De Neef","sequence":"additional","affiliation":[{"name":"Radiopharmacy Department, Montpellier University Hospital, University of Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Kouyoumdjian","sequence":"additional","affiliation":[{"name":"Radiopharmacy Department, Montpellier University Hospital, University of Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Palenzuela","sequence":"additional","affiliation":[{"name":"Pediatric Hematology-Oncology Department, Montpellier University Hospital, University of Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Tunez","sequence":"additional","affiliation":[{"name":"Haemovigilance Department, Montpellier University Hospital, University of Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Mariano-Goulart","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, Montpellier University Hospital, University of Montpellier, Montpellier, France"},{"name":"PhyMedExp, INSERM U1046, CNRS UMR 9214, Montpellier University Hospital, University of Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Bourdon","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, Montpellier University Hospital, University of Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Paunet","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, Montpellier University Hospital, University of Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"bibr1-15353508241293961","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1971.tb07057.x"},{"key":"bibr2-15353508241293961","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1991.tb04532.x"},{"issue":"2","key":"bibr3-15353508241293961","first-page":"182","volume":"34","author":"Lamy T","year":"1993","journal-title":"J Nucl Med Off Publ Soc Nucl Med"},{"key":"bibr4-15353508241293961","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.832723.x"},{"key":"bibr5-15353508241293961","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318271f457"},{"key":"bibr6-15353508241293961","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15090"},{"key":"bibr7-15353508241293961","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-93646-2"},{"key":"bibr8-15353508241293961","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19145"},{"key":"bibr9-15353508241293961","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1985.tb07392.x"},{"issue":"7","key":"bibr10-15353508241293961","first-page":"1135","volume":"38","author":"Hammersmith SM","year":"1997","journal-title":"J Nucl Med Off Publ Soc Nucl Med"},{"key":"bibr11-15353508241293961","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-198407000-00004"},{"key":"bibr12-15353508241293961","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V70.3.652.652"},{"key":"bibr13-15353508241293961","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-2998(84)80025-2"},{"key":"bibr14-15353508241293961","unstructured":"Bonnes pratiques de pr\u00e9paration. 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