{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:13:18Z","timestamp":1788585198789,"version":"build-2803163510"},"reference-count":23,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007013","name":"F. Hoffmann-La Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007013","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wellcome Trust Digital Award","award":["215747\/Z\/19\/Z"],"award-info":[{"award-number":["215747\/Z\/19\/Z"]}]},{"DOI":"10.13039\/501100024370","name":"Ministero dell'Istruzione e del Merito","doi-asserted-by":"publisher","award":["Law 232\/2016"],"award-info":[{"award-number":["Law 232\/2016"]}],"id":[{"id":"10.13039\/501100024370","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_A656_5QD30_2135, MC_A654-5QB40"],"award-info":[{"award-number":["MC_A656_5QD30_2135, MC_A654-5QB40"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["094849\/Z\/10\/Z"],"award-info":[{"award-number":["094849\/Z\/10\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Imaging"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Elevated dopamine synthesis capacity is part of the pathophysiology of schizophrenia thought to underlie psychosis. Drugs that reduce this phenomenon could thus be potential treatments for these disorders. In this study, we evaluated the ability of the trace amine-associated receptor 1 (TAAR1) partial agonist ralmitaront to reduce presynaptic dopamine synthesis capacity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedures<\/jats:title>\n                    <jats:p>\n                      Ralmitaront (3 mg\/kg, i.p.), a TAAR1 partial agonist, was evaluated using [\n                      <jats:sup>18<\/jats:sup>\n                      F]DOPA PET for its ability to modulate presynaptic dopamine synthesis capacity in na\u00efve mice as well as mice in an induced hyperdopaminergic state following acute cocaine administration (20 mg\/kg, i.p.).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cocaine treatment on its own did not induce elevated dopamine synthesis capacity when compared to the control group. Pretreatment with ralmitaront significantly reduced dopamine synthesis capacity when given either alone (44%) or in combination with the psychostimulant cocaine (50%) when compared to the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The TAAR1 agonist ralmitaront reduces striatal dopamine synthesis capacity, indexed as Ki\n                      <jats:sup>Mod<\/jats:sup>\n                      , both in na\u00efve animals and when given prior to acute cocaine. This indicates the potential of TAAR1 agonism to address disorders characterized by striatal hyperdopaminergia.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15353508241299546","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T09:15:08Z","timestamp":1734513308000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of the TAAR1 Partial Agonist Ralmitaront on Presynaptic Dopamine Synthesis Capacity Measured Using  [\n                    <sup>18<\/sup>\n                    F]DOPA PET in Na\u00efve and Cocaine-Treated Mice"],"prefix":"10.1177","volume":"23","author":[{"given":"David R.","family":"Bonsall","sequence":"first","affiliation":[{"name":"Psychiatric Imaging Group, MRC Laboratory of Medical Sciences (LMS), London, UK"},{"name":"Invicro, Burlington Danes, Hammersmith Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Kokkinou","sequence":"additional","affiliation":[{"name":"Psychiatric Imaging Group, MRC Laboratory of Medical Sciences (LMS), London, UK"},{"name":"Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5814-0899","authenticated-orcid":false,"given":"Els F.","family":"Halff","sequence":"additional","affiliation":[{"name":"Psychiatric Imaging Group, MRC Laboratory of Medical Sciences (LMS), London, UK"},{"name":"Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazia","family":"Rutigliano","sequence":"additional","affiliation":[{"name":"Psychiatric Imaging Group, MRC Laboratory of Medical Sciences (LMS), London, UK"},{"name":"Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sac-Pham","family":"Tang","sequence":"additional","affiliation":[{"name":"Invicro, Burlington Danes, Hammersmith Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3562-0683","authenticated-orcid":false,"given":"Mattia","family":"Veronese","sequence":"additional","affiliation":[{"name":"Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK"},{"name":"Department of Information Engineering, University of Padua, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine E.","family":"Irvine","sequence":"additional","affiliation":[{"name":"Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK"},{"name":"Metabolic Signalling Group, MRC Laboratory of Medical Sciences (LMS), London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic J.","family":"Withers","sequence":"additional","affiliation":[{"name":"Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK"},{"name":"Metabolic Signalling Group, MRC Laboratory of Medical Sciences (LMS), London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Wells","sequence":"additional","affiliation":[{"name":"Invicro, Burlington Danes, Hammersmith Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7499-1714","authenticated-orcid":false,"given":"Sridhar","family":"Natesan","sequence":"additional","affiliation":[{"name":"Psychiatric Imaging Group, MRC Laboratory of Medical Sciences (LMS), London, UK"},{"name":"Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Gerlach","sequence":"additional","affiliation":[{"name":"Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. 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