{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:47:52Z","timestamp":1788922072989,"version":"build-2803163510"},"reference-count":70,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T00:00:00Z","timestamp":1746921600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T00:00:00Z","timestamp":1746921600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["P51 OD011107"],"award-info":[{"award-number":["P51 OD011107"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 MH125411"],"award-info":[{"award-number":["R01 MH125411"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["S10 OD021715"],"award-info":[{"award-number":["S10 OD021715"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["U54 NS127758"],"award-info":[{"award-number":["U54 NS127758"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Imaging"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      The kappa opioid receptor (KOR) plays a pivotal role in stress- and anxiety-related behaviors, with growing evidence linking it to stress induced by social isolation and separation. Despite this, tools for studying KOR in clinically relevant social contexts remain limited. The socially monogamous coppery titi monkey offers a translational model for investigating pair bonding. This study evaluated the feasibility of [\n                      <jats:sup>11<\/jats:sup>\n                      C]GR103545 PET imaging to characterize KOR activity\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      , and its pharmacological blockade for the first time in titi monkeys.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Adult titi monkeys (N\u2009=\u20096) underwent [\n                      <jats:sup>11<\/jats:sup>\n                      C]GR103545 PET brain scans at baseline and following administration of the KOR antagonist CERC-501. Non-displaceable binding potential (BP\n                      <jats:sub>ND<\/jats:sub>\n                      ) was calculated across 14 brain volumes of interest (VOIs) implicated in social bonding, using Simplified and Logan reference tissue models (SRTM and LRTM), with the cerebellum as the reference region.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline [\n                      <jats:sup>11<\/jats:sup>\n                      C]GR103545 uptake patterns across VOIs were consistent with reports in humans, other primates and published autoradiography data. CERC-501 pretreatment significantly reduced BP\n                      <jats:sub>ND<\/jats:sub>\n                      (SRTM: 55.99%, LRTM: 59.68%) across several, but not all brain VOIs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study establishes [\n                      <jats:sup>11<\/jats:sup>\n                      C]GR103545 PET as a viable tool for assessing KOR binding dynamics in titi monkeys, providing new opportunities to explore KOR modulation in social bonding and separation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15353508251341082","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:27:47Z","timestamp":1747009667000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Mapping Kappa Opioid Receptor Binding in Titi Monkeys with [\n                    <sup>11<\/sup>\n                    C]GR103545 PET"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3055-3187","authenticated-orcid":false,"given":"Alita Jesal D","family":"Almeida","sequence":"first","affiliation":[{"name":"University of California-Davis College of Engineering"},{"name":"University of California-Davis School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5398-438X","authenticated-orcid":false,"given":"Brad A.","family":"Hobson","sequence":"additional","affiliation":[{"name":"University of California-Davis College of Engineering"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Logan E.","family":"Savidge","sequence":"additional","affiliation":[{"name":"University of California-Davis College of Letters and Science"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Manca","sequence":"additional","affiliation":[{"name":"University of California-Davis College of Letters and Science"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Paulus","sequence":"additional","affiliation":[{"name":"University of California-Davis Center for Neuroscience"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Bales","sequence":"additional","affiliation":[{"name":"University of California-Davis College of Letters and Science"},{"name":"California National Primate Research Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4211-1900","authenticated-orcid":false,"given":"Abhijit J.","family":"Chaudhari","sequence":"additional","affiliation":[{"name":"University of California-Davis School of Medicine"},{"name":"University of California-Davis College of Engineering"},{"name":"California National Primate Research Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,11]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(82)90374-5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2015.01.001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010919-023317"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.046433"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.09.021"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4458-07.2008"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-013-3195-5"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.08.062"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2021.0061"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5779-11.2012"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2012-0068"},{"issue":"4","key":"e_1_3_2_13_2","first-page":"652","article-title":"Longitudinal correlates of loneliness and psychological distress during the lockdown situation due to COVID-19","volume":"77","author":"Losada-Baltar A","year":"2022","unstructured":"Losada-Baltar A, Mart\u00ednez-Huertas J\u00c1, Jim\u00e9nez-Gonzalo L, et al. Longitudinal correlates of loneliness and psychological distress during the lockdown situation due to COVID-19. Effects of Age and Self-Perceptions of Aging. The Journals of Gerontology: Series B. 2022;77(4):652\u2013660.","journal-title":"Effects of Age and Self-Perceptions of Aging. The Journals of Gerontology: Series B"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.15325"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24224190"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","unstructured":"Placzek MS. Imaging Kappa opioid receptors in the living brain with positron emission tomography. 2021 pp. 547\u2013577.","DOI":"10.1007\/164_2021_498"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.2174\/138161207779313821"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00593"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.119.227694"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2016.09.005"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.6b00268"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.195586"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-010-1384-6"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/syn.22042"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0398-4"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2021.113927"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.191489"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2021.105062"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1327"},{"issue":"3","key":"e_1_3_2_30_2","first-page":"373","article-title":"Titi monkeys as a novel non-human primate model for the neurobiology of pair bonding","volume":"90","author":"Bales KL","year":"2017","unstructured":"Bales KL, Arias Del Razo R, Conklin QA, et al. Titi monkeys as a novel non-human primate model for the neurobiology of pair bonding. Yale J Biol Med. 2017;90(3):373\u2013387.","journal-title":"Yale J Biol Med"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2016.03.004"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2020.00025"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2010.08.014"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00293"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1361-8415(02)00054-3"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2010.2046908"},{"key":"e_1_3_2_37_2","unstructured":"Avants BB Tustison N Johnson H. Advanced Normalization Tools (ANTS) Release 2.x https:\/\/brianavants.wordpress.com\/2012\/04\/13\/updated-ants-compile-instructions-april-12-2012\/ (2014)."},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2007.06.004"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1996.0066"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199609000-00008"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.112672"},{"issue":"3","key":"e_1_3_2_42_2","first-page":"484","article-title":"11C-GR103545, A radiotracer for imaging kappa-opioid receptors in vivo with PET: Synthesis and evaluation in baboons","volume":"46","author":"Talbot PS","year":"2005","unstructured":"Talbot PS, Narendran R, Butelman ER, et al. 11C-GR103545, A radiotracer for imaging kappa-opioid receptors in vivo with PET: Synthesis and evaluation in baboons. J Nucl Med. 2005;46(3):484\u2013494.","journal-title":"J Nucl Med"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1937.10503522"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/93.3.491"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1109\/TAC.1974.1100705"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.01.023"},{"key":"e_1_3_2_47_2","article-title":"Determining pharmacological selectivity of the kappa opioid receptor antagonist LY2456302 using pupillometry as a translational biomarker in rat and human","volume":"18","author":"Rorick-Kehn LM","year":"2015","unstructured":"Rorick-Kehn LM, Witcher JW, Lowe SL, et al. Determining pharmacological selectivity of the kappa opioid receptor antagonist LY2456302 using pupillometry as a translational biomarker in rat and human. Int J Neuropsuchopharmacolog. 2015;18(2). Epub ahead of print February DOI: https:\/\/doi.org\/10.1093\/ijnp\/pyu036","journal-title":"Int J Neuropsuchopharmacolog"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-018-0015-y"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.05.033"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-016-0016-y"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.03.042"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2008.09.009"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.107831"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0406-22.2023"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-018-0199-1"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.854494"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291723002866"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1613"},{"key":"e_1_3_2_59_2","article-title":"Neural evidence of functional compensation for fluid intelligence in healthy ageing","volume":"13","author":"Knights E","year":"2024","unstructured":"Knights E, Henson RN, Morcom A, Mitchell DJ, Tsvetanov KA. Neural evidence of functional compensation for fluid intelligence in healthy ageing. Epub ahead of print. 2024;13. DOI: https:\/\/doi.org\/10.7554\/eLife.93327.2.","journal-title":"Epub ahead of print"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2023.105489"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2022.994504"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.04.256"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-08-03483.2003"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.2580310202"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-8051(99)00043-8"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.109512"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-8051(01)00285-2"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-8051(00)00137-2"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.07.046"},{"issue":"12","key":"e_1_3_2_70_2","first-page":"2083","article-title":"Effects of statistical noise on graphic analysis of PET neuroreceptor studies","volume":"41","author":"Slifstein M","year":"2000","unstructured":"Slifstein M, Laruelle M. Effects of statistical noise on graphic analysis of PET neuroreceptor studies. J Nucl Med. 2000;41(12):2083\u20132088.","journal-title":"J Nucl Med"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-009-1293-8"}],"container-title":["Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15353508251341082","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15353508251341082","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15353508251341082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:27:14Z","timestamp":1777703234000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15353508251341082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,11]]},"references-count":70,"alternative-id":["10.1177\/15353508251341082"],"URL":"https:\/\/doi.org\/10.1177\/15353508251341082","relation":{},"ISSN":["1535-3508","1536-0121"],"issn-type":[{"value":"1535-3508","type":"print"},{"value":"1536-0121","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,11]]},"article-number":"15353508251341082"}}