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To achieve localized STING activation and robust systemic immunity, we combined STING agonism with photodynamic therapy (PDT), creating a carrier-free nanoplatform (Ce6&amp;SR717 NPs) through self-assembly of SR717 (STING agonist) and Ce6 (chlorin e6, photosensitizer). This excipient-free design achieves maximum drug loading, alleviates carrier-related safety issues, and realizes the spatiotemporally synchronized activation of PDT-induced immunogenic cell death and STING signaling through irradiation, which establishes an auto-amplifying cycle of on-site antigen release and systemic immune priming. In the murine breast cancer model, Ce6&amp;SR717 NPs plus laser irradiation dramatically increased CD8\n                    <jats:sup>+<\/jats:sup>\n                    T-cell infiltration within the tumor, triggered strong systemic antitumor immunity, and suppressed both primary and distant tumors. Collectively, these results identify Ce6&amp;SR717 NPs as a safe and efficient modality for synergistic photo-immunotherapy of immunologically cold tumors.\n                  <\/jats:p>","DOI":"10.1177\/15353508261464127","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:36:32Z","timestamp":1782448592000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Carrier-Free Ce6&amp;SR717 Nanomedicine Enables Abscopal Photoimmunotherapy via cGAS-STING Activation in Breast Cancer"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4449-8845","authenticated-orcid":false,"given":"Xin","family":"Peng","sequence":"first","affiliation":[{"name":"Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University"},{"name":"NHC Key Laboratory of Birth Defect for Research and Prevention (Hunan Provincial Maternal and Child Health 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