{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T12:37:43Z","timestamp":1786451863662,"version":"build-2736575974"},"reference-count":33,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Frontier Technologies R&D Program of Jiangsu","award":["BF2025627"],"award-info":[{"award-number":["BF2025627"]}]},{"name":"Nanjing Outstanding Youth Talent Program","award":["JQX25013"],"award-info":[{"award-number":["JQX25013"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82202128"],"award-info":[{"award-number":["82202128"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Imaging"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>\n                    This study investigated time-dependent group-level changes in chemical exchange saturation transfer (CEST) signals in a mouse model and explored utility in identifying stroke onset time. Multiparametric magnetic resonance imaging (diffusion weighted imaging, arterial spin labeling, and CEST) was conducted on 12 normal and 26 ischemic mice. Imaging findings were validated by immunohistochemical analysis. CEST parameters in infarct and penumbra were compared between strokes within 4.5\u2005h and over 4.5\u2005h. Correlations, regression, and receiver operating characteristic curves evaluated performance. Infarct guanidine, magnetization transfer (MT), nuclear Overhauser enhancement (NOE) (\u22123.5\u2005ppm), and NOE (\u22121.6\u2005ppm) significantly differed between groups and associated with onset time (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.01). MT, NOE (\u22123.5\u2005ppm), NOE (\u22121.6\u2005ppm) showed significant associations with onset time in univariate logistic regression (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.05). The NOE (\u22123.5\u2005ppm) achieved an area under the curve of 0.848 (95% CI: 0.655-1.000), outperforming apparent diffusion coefficient (\n                    <jats:italic toggle=\"yes\">z<\/jats:italic>\n                    \u2009=\u2009\u22122.397,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.017) and cerebral blood flow (\n                    <jats:italic toggle=\"yes\">z<\/jats:italic>\n                    \u2009=\u2009\u22122.271,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.0271). NOE (\u22123.5\u2005ppm) signals and lipid peroxidation both declined progressively with ischemic duration. These findings indicate that NOE (\u22123.5\u2005ppm) signal attenuation parallels lipid peroxidation and may indicate progressive membrane lipid loss in ischemia.\n                  <\/jats:p>","DOI":"10.1177\/15353508261477596","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T17:44:01Z","timestamp":1786211041000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multiparametric CEST MRI for Time-Associated Characterization of Acute Ischemic Stroke: NOE (\u22123.5\u2005ppm) Signal as a Potential Imaging Biomarker"],"prefix":"10.1177","volume":"25","author":[{"given":"Zitong","family":"Min","sequence":"first","affiliation":[{"name":"Nanjing First Hospital, Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yupeng","family":"Wu","sequence":"additional","affiliation":[{"name":"East China Normal University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjie","family":"Huang","sequence":"additional","affiliation":[{"name":"Nanjing First Hospital, Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifan","family":"Pang","sequence":"additional","affiliation":[{"name":"East China Normal University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xu","sequence":"additional","affiliation":[{"name":"Nanjing First Hospital, Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyang","family":"Peng","sequence":"additional","affiliation":[{"name":"Nanjing First Hospital, Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyou","family":"Chen","sequence":"additional","affiliation":[{"name":"Nanjing First Hospital, Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xindao","family":"Yin","sequence":"additional","affiliation":[{"name":"Nanjing First Hospital, Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqi","family":"Li","sequence":"additional","affiliation":[{"name":"East China Normal University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6111-7948","authenticated-orcid":false,"given":"Liang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Nanjing First Hospital, Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.004075"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30314-4"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000211"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.035425"},{"issue":"12","key":"e_1_3_3_6_2","article-title":"Intravenous thrombolytic treatment and endovascular thrombectomy for ischaemic wake-up stroke","volume":"12","author":"Roaldsen MB","year":"2021","unstructured":"Roaldsen MB, Lindekleiv H, Mathiesen EB. Intravenous thrombolytic treatment and endovascular thrombectomy for ischaemic wake-up stroke. Cochrane Database Syst Rev. 2021;12(12):CD010995.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2022.02.013"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70192-2"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.001001"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.040830"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4850"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2024.03.034"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26829"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/tomography8020060"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-023-2785-7"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.06.007"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4711"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.12"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-016-2258-y"},{"issue":"1","key":"e_1_3_3_20_2","first-page":"1","article-title":"CEST signal at 2 ppm (CEST@2 ppm) from Z-spectral fitting correlates with creatine distribution in brain tumor","volume":"28","author":"Cai K","year":"2015","unstructured":"Cai K, Singh A, Poptani H, et al. CEST signal at 2 ppm (CEST@2 ppm) from Z-spectral fitting correlates with creatine distribution in brain tumor. NMRBiomed. 2015;28(1):1\u20138.","journal-title":"NMRBiomed"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.30134"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29408"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29691"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4778"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29643"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.03.047"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4356"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.21037\/qims-23-510"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2011.05.001"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.2887"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm907"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-017-2664-9"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/ae4167"},{"issue":"6","key":"e_1_3_3_34_2","first-page":"2404","article-title":"Enhancing SNR in CEST imaging: A deep learning approach with a denoising convolutional autoencoder","volume":"92","author":"Kurmi Y","year":"2024","unstructured":"Kurmi Y, Viswanathan M, Zu Z. Enhancing SNR in CEST imaging: A deep learning approach with a denoising convolutional autoencoder. Magn Reson Med. 2024;92(6):2404\u20132419.","journal-title":"Magn Reson Med"}],"container-title":["Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15353508261477596","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15353508261477596","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15353508261477596","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T12:03:40Z","timestamp":1786449820000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15353508261477596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":33,"alternative-id":["10.1177\/15353508261477596"],"URL":"https:\/\/doi.org\/10.1177\/15353508261477596","relation":{},"ISSN":["1535-3508","1536-0121"],"issn-type":[{"value":"1535-3508","type":"print"},{"value":"1536-0121","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"article-number":"15353508261477596"}}