{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:37:25Z","timestamp":1777873045378,"version":"3.51.4"},"reference-count":28,"publisher":"Frontiers Media SA","issue":"6","license":[{"start":{"date-parts":[[2001,6,1]],"date-time":"2001-06-01T00:00:00Z","timestamp":991353600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Biol Med (Maywood)"],"published-print":{"date-parts":[[2001,6]]},"abstract":"<jats:p>\n                    Ectopic overexpression of the murine agouti gene results in yellow coat color, obesity, hyperinsulinemia, and type II diabetes. We have shown the human homologue of agouti (agouti signaling protein; ASP) to regulate human adipocyte metabolism and lipid storage via a Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -dependent mechanism. We have also demonstrated agouti expression in human pancreas, and that ASP stimulates insulin release via a similar Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -dependent mechanism. Plasma amylin is also elevated in agouti mutant mice. Amylin is cosecreted with insulin from \u03b2-cells, and overexpression of human amylin in \u03b2-cells in yellow agouti mutant mice resulted in accelerated pancreatic amyloid deposition, severely impaired \u03b2-cell function, and a diabetic phenotype. We report here that ASP stimulates amylin release in both the HIT-T15 \u03b2-cell line and human pancreatic islets in the presence of a wide range of glucose concentrations (0\u201316.7 mmol\/L), similar to its effect on insulin release; this effect was blocked by 30 \u03bcmol\/L nitrendipine, confirming a Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -dependent mechanism. Accordingly, ASP stimulation of amylin release may serve as a compensatory system to regulate blood glucose in yellow agouti mutants.\n                  <\/jats:p>","DOI":"10.1177\/153537020122600609","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T03:36:06Z","timestamp":1500521766000},"page":"565-569","source":"Crossref","is-referenced-by-count":1,"title":["Agouti Signaling Protein Stimulates Islet Amyloid Polypeptide (Amylin) Secretion in Pancreatic \u03b2-Cells"],"prefix":"10.3389","volume":"226","author":[{"given":"Bingzhong","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Nutrition, University of Tennessee, Knoxville, Tennessee 37996"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B.","family":"Zemel","sequence":"additional","affiliation":[{"name":"Department of Nutrition, University of Tennessee, Knoxville, Tennessee 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