{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:56:48Z","timestamp":1782939408114,"version":"3.54.5"},"reference-count":38,"publisher":"Frontiers Media SA","issue":"4","license":[{"start":{"date-parts":[[2015,11,8]],"date-time":"2015-11-08T00:00:00Z","timestamp":1446940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Exp Biol Med (Maywood)"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p>Saururus chinensis (Lour.) Baill. is a perennial plant distributed throughout Northeast Asia and its roots have been widely used as a traditional medicine for hepatitis, asthma, pneumonia, and gonorrhea. This study was designed to investigate the anti-inflammatory activity of an extract of S. chinensis of the aerial parts (rather than the root), and the signaling pathway responsible for this effect in lipopolysaccharide-stimulated murine macrophages. The subfraction 4 (SCF4) from the n-hexane layer of the ethanol extract of the aerial parts of S. chinensis exhibited the highest nitrite-inhibitory activity. SCF4 significantly inhibited the production of nitrite and the expression of pro-inflammatory mediators via heme oxygenase-1 upregulation. SCF4 caused significant phosphorylation of p38 MAPK and Akt, which subsequently induced the nuclear translocation of p-p65 nuclear factor-\u03baB and Nrf2. SCF4 also suppressed the phosphorylation of signal transducers and activators of transcription 1 (p-STAT1). The heme oxygenase-1 inhibitor zinc protoporphyrin attenuated the inhibitory effect of SCF4 on lipopolysaccharide-stimulated nitrite production and expression of inflammatory mediators, tumor necrosis factor alpha, and p-STAT1. We identified sauchinone as the active compound in S. chinensis extract and SCF4. Sauchinone was shown to significantly inhibit nitrite production and inflammatory mediators expression via heme oxygenase-1 upregulation. These results suggest that S. chinensis extract, SCF4, and its active compound, sauchinone, could be used as an anti-inflammatory agent.<\/jats:p>","DOI":"10.1177\/1535370215614657","type":"journal-article","created":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T20:08:11Z","timestamp":1447099691000},"page":"396-408","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Anti-inflammatory effects of\n                    <i>Saururus chinensis<\/i>\n                    aerial parts in murine macrophages via induction of heme oxygenase-1"],"prefix":"10.3389","volume":"241","author":[{"given":"Xue","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Life Science, Gachon University, Seongnam 461-701, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inhye","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Life Science, Gachon 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