{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:13:21Z","timestamp":1790712801783,"version":"4.1.0"},"reference-count":89,"publisher":"Frontiers Media SA","issue":"5","license":[{"start":{"date-parts":[[2015,12,6]],"date-time":"2015-12-06T00:00:00Z","timestamp":1449360000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Exp Biol Med (Maywood)"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>Advances in depression research have targeted inflammation and oxidative stress to develop novel types of treatment. The JAK\/STAT signaling pathway plays pivotal roles in immune and inflammatory responses. The present study was designed to investigate the effects of N-acetylcysteine, a putative precursor of the antioxidant glutathione, in an animal model of depression, with an emphasis on the JAK\/STAT signaling pathway. Fluoxetine, a classical antidepressant drug was also under investigation. Male Wistar rats were subjected to forced swimming test and given N-acetylcysteine and fluoxetine immediately after the pre-test session, 5\u2009h later and 1\u2009h before the test session of the forced swimming test. N-acetylcysteine decreased immobility time ( P\u2009&lt;\u20090.05), serum corticosterone ( P\u2009&lt;\u20090.001), and hydrogen peroxide ( P\u2009&lt;\u20090.001), while restored glutathione concentration. Treatment of the rats with N-acetylcysteine produced significant ( P\u2009&lt;\u20090.001) down-regulation of STAT3 mRNA expression and protein phosphorylation. On the other hand, N-acetylcysteine significantly ( P\u2009&lt;\u20090.001) increased SOCS3 gene expression; however, SOCS3 protein was not changed. In conclusion, our study suggests that modulation of the JAK\/STAT pathway might mediate the antidepressant-like effects of N-acetylcysteine. Therefore, depression research may target the JAK\/STAT signaling pathway to provide a novel effective therapy.<\/jats:p>","DOI":"10.1177\/1535370215619707","type":"journal-article","created":{"date-parts":[[2015,12,8]],"date-time":"2015-12-08T19:42:54Z","timestamp":1449603774000},"page":"509-518","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":47,"title":["Possible involvement of the JAK\/STAT signaling pathway in N-acetylcysteine-mediated antidepressant-like effects"],"prefix":"10.3389","volume":"241","author":[{"given":"Marwa M","family":"Al-Samhari","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 12372, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouf M","family":"Al-Rasheed","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy, King 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