{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:36:55Z","timestamp":1777873015241,"version":"3.51.4"},"reference-count":26,"publisher":"Frontiers Media SA","issue":"16","license":[{"start":{"date-parts":[[2016,7,24]],"date-time":"2016-07-24T00:00:00Z","timestamp":1469318400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Exp Biol Med (Maywood)"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>Compared with conventional aortic cross-clamping, endovascular balloon occlusion (EBO) is a valuable strategy in unstable ruptured abdominal aorta aneurysm patients; however, it is unclear how long the balloon may remain safely inflated. Using a porcine model, we evaluated the influence of different EBO time periods on intra-abdominal pressure (IAP) and the association between various pathophysiologic indicators and reperfusion time. Twelve healthy three-month-old domestic piglets were subjected to ischemia\/reperfusion injury using EBO within the abdominal aorta. Animals were grouped as A, B, and C based on 30, 60, or 120\u2009min of ischemic time, respectively. Changes in IAP, hemodynamic data, respiratory and renal function, and histology after reperfusion were compared with baseline measurements. All pigs gradually developed intra-abdominal hypertension after ischemia\/reperfusion injury. IAP increased significantly after 4\u2009h of reperfusion in all three groups (all P\u2009&lt;\u20090.001) with maximal IAP reaching\u2009&gt;\u200922\u2009mmHg in 10 pigs. However, no significant intergroup differences were found. Cardiac output remained stable, but mixed venous oxygen saturation decreased significantly at 4\u2009h after reperfusion (P\u2009&lt;\u20090.05). The pH decreased significantly at 10\u2009min in all three groups (all P\u2009&lt;\u20090.001). Histological changes in the small intestine, lung, and kidney occurred secondary to aortic ischemia; however, no significant differences were noted between groups (P\u2009&gt;\u20090.05). EBO within the abdominal aorta induced ischemia\/reperfusion injury which led to intra-abdominal hypertension, pathological changes within multiple organs, and decreased mixed venous oxygen saturation after only 30\u2009min of abdominal aortic ischemia.<\/jats:p>","DOI":"10.1177\/1535370216648802","type":"journal-article","created":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T20:24:11Z","timestamp":1464035051000},"page":"1834-1843","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Original Research: Porcine model for observing changes due to ischemia\/reperfusion injury secondary to intra-abdominal endovascular balloon occlusion"],"prefix":"10.3389","volume":"241","author":[{"given":"Chia-Sheng","family":"Chao","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Surgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan, R.O.C."},{"name":"School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan, R.O.C."},{"name":"Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan, R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien-Sung","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan, R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao-Horng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nursing, Yuanpei University, Hsinchu City 30015, Taiwan, R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Hao","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan, R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan, R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yee-Phoung","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan, R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsien-Kuo","family":"Chin","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan, R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang-Tao","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kaohsiung 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