{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:38:45Z","timestamp":1793313525114,"version":"4.5.0"},"reference-count":39,"publisher":"Frontiers Media SA","issue":"1","license":[{"start":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T00:00:00Z","timestamp":1471824000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Exp Biol Med (Maywood)"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>\n                    The interstitial lung diseases are poorly understood and there are currently no studies evaluating the association of physical exercise with an ACE2 activator (DIZE) as a possible treatment for this group of diseases. We evaluate the effects of pharmacological treatment with an angiotensin-converting enzyme 2 activator drug, associated with exercise, on the pulmonary lesions induced by bleomycin. From the 96 male Balb\/c mice used in the experiment, only 49 received 8 U\/kg of bleomycin (BLM, intratracheally). The mice were divided into control (C) and bleomycin (BLM) groups, sedentary and trained (C-SED, C-EXE, BLM-SED, BLM-EXE), control and bleomycin and also sedentary and trained treated with diminazene (C-SED\/E, C-EXE\/E, BLM-SED\/E, BLM-EXE\/E). The animals were trained five days\/week, 1\u2009h\/day with 60% of the maximum load obtained in a functional capacity test, for four weeks. Diminazene groups were treated (1\u2009mg\/kg, by gavage) daily until the end of the experiment. The lungs were collected 48\u2009h after the training program, set in buffered formalin and investigated by Gomori\u2019s trichrome, immunohistochemistry of collagen type I, TGF-\u03b2\n                    <jats:sub>1<\/jats:sub>\n                    , beta-prolyl-4-hydroxylase, MMP-1 and -2. The BLM-EXE\/E group obtained a significant increase in functional capacity, reduced amount of fibrosis and type I collagen, decreased expression of TGF-\u03b2\n                    <jats:sub>1<\/jats:sub>\n                    and beta-prolyl-4-hydroxylase and an increase of metalloproteinase \u22121, \u22122 when compared with the other groups. The present research shows, for the first time, that exercise training associated with the activation of ACE2 potentially reduces pulmonary fibrosis.\n                  <\/jats:p>","DOI":"10.1177\/1535370216665174","type":"journal-article","created":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T20:08:25Z","timestamp":1471896505000},"page":"8-21","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":44,"title":["Original Research: ACE2 activator associated with physical exercise potentiates the reduction of pulmonary fibrosis"],"prefix":"10.3389","volume":"242","author":[{"given":"Luana O","family":"Prata","sequence":"first","affiliation":[{"name":"Departamento de Patologia Geral, Instituto de Ci\u00eancias Biol\u00f3gicas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, CEP 31 270-901, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina R","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Departamento de Patologia Geral, Instituto de Ci\u00eancias Biol\u00f3gicas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, CEP 31 270-901, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica M","family":"Martins","sequence":"additional","affiliation":[{"name":"Departamento de Patologia Geral, Instituto de Ci\u00eancias Biol\u00f3gicas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, CEP 31 270-901, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula C","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Departamento de Patologia Geral, Instituto de Ci\u00eancias Biol\u00f3gicas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, CEP 31 270-901, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabr\u00edcio Marcus 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