{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:00:34Z","timestamp":1789707634931,"version":"4.0.1"},"reference-count":67,"publisher":"Frontiers Media SA","issue":"13","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e1 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2010\/18353-9"],"award-info":[{"award-number":["2010\/18353-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Exp Biol Med (Maywood)"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>The aim of this study was to investigate the association of five polymorphisms in the IL1A and IL1B genes in Brazilian patients with primary open angle glaucoma (POAG). A case\u2013control study, including 214 unrelated POAG patients and 187 healthy individuals, was conducted to evaluate the frequency of polymorphisms in the IL1A and IL1B genes. Ophthalmic evaluation was performed and genomic DNA was obtained from all participants. Five single nucleotide polymorphisms (SNPs): IL1A (\u2013889C\/T: rs1800587:C\u2009&gt;\u2009T, +4845G\/T:rs17561G&gt;T) and IL1B (\u201331C\/T:rs1143627:T\u2009&gt;\u2009C, \u2013511C\/T:rs16944C&gt;T and +3954C\/T:rs1143634:C\u2009&gt;\u2009T) were genotyped through direct sequencing. The association of individual SNPs was tested using logistic regression. There was an association between the \u201331C\/T and \u2013511 C\/T polymorphisms in the IL1B gene with POAG (p\u2009=\u20090.002 and p\u2009=\u20090.009, respectively). High linkage disequilibrium was observed between the \u201331C\/T and \u2013511C\/T polymorphisms. The statistical analysis showed that the T\/C haplotype (\u201331\/\u2013511) in the IL1B gene is more frequent in controls (p\u2009=\u20090.011) and the C\/T haplotype (\u201331\/\u2013511) is more common in POAG patients (p\u2009=\u20090.018). Among POAG cases, the genotypic distribution of the \u201331C\/T and \u2013511 C\/T SNPs was significantly different in patients who underwent anti-glaucomatous surgery compared to patients without surgery (p\u2009=\u20090.016 and 0.023, respectively). There was no statistically significant difference for the remaining SNPs between POAG patients and controls. In conclusion, the C allele of the \u201331C\/T and the T allele of the \u2013511C\/T polymorphisms in the IL1B gene may represent a \u201crisk haplotype\u201d for the development of POAG in Brazilian individuals. Further studies with larger cohorts of patients are necessary to substantiate these findings.<\/jats:p>","DOI":"10.1177\/1535370218809709","type":"journal-article","created":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T08:54:41Z","timestamp":1542876881000},"page":"1083-1091","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Association between\n                    <i>IL1A<\/i>\n                    and\n                    <i>IL1B<\/i>\n                    polymorphisms and primary open angle glaucoma in a Brazilian population"],"prefix":"10.3389","volume":"243","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1726-7460","authenticated-orcid":false,"given":"Mariana B","family":"Oliveira","sequence":"first","affiliation":[{"name":"Laboratory of Human Genetics, Center for Molecular Biology and Genetic Engineering, CBMEG, University of Campinas, SP 13083-875, 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