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A societal consequence of osteoporosis is the substantial burden that it inflicts upon patients and their families. Several bone-modifying drugs have been prescribed to patients with osteoporosis. However, evidence for their anti-fracture efficacy remains inconclusive. To the contrary, long-term use of anti-osteoporotic drugs such as bisphosphonates and Denosumab, an RANKL inhibitor, have resulted in adverse events. We now present an alternative and adjuvant approach for treatment of osteoporosis. The data derive from in vivo studies in an ovariectomized rat model and from a randomized double blind, placebo-controlled human clinical study. Both studies involved treatment with Panaceo Micro Activation (PMA)-zeolite-clinoptilolite, a defined cation exchange clinoptilolite, which clearly improved all bone histomorphometric parameters examined from ovariectomized animals, indicative for increased bone formation. Moreover, intervention with PMA-zeolite-clinoptilolite for one year proved safe in humans. Furthermore, patients treated with PMA-zeolite-clinoptilolite showed an increase in bone mineral density, an elevated level of markers indicative of bone formation, a significant reduction in pain, and significantly improved quality of life compared with patients in the control (placebo) group. These encouraging positive effects of PMA-zeolite-clinoptilolite on bone integrity and on osteoporosis warrant further evaluation of treatment with PMA-zeolite-clinoptilolite as a new alternative adjuvant therapy for osteoporosis.<\/jats:p>","DOI":"10.1177\/1535370220968752","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T02:38:40Z","timestamp":1605235120000},"page":"529-537","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial"],"prefix":"10.3389","volume":"246","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0491-673X","authenticated-orcid":false,"given":"Sandra","family":"Kraljevi\u0107 Paveli\u0107","sequence":"first","affiliation":[{"name":"Faculty of Health Studies, University of Rijeka, 51000 Rijeka, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vedran","family":"Micek","sequence":"additional","affiliation":[{"name":"Institute for Medical Research and Occupational Health, 10001 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragica","family":"Bobinac","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia"},{"name":"Clinic for Surgery, Clinical Hospital Rijeka, 51000 Rijeka, Croatia"},{"name":"Faculty of Medicine, Juraj Dobrila University of Pula, 52100 Pula, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edo","family":"Bazdulj","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia"},{"name":"Clinic for Surgery, Clinical Hospital Rijeka, 51000 Rijeka, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2457-3618","authenticated-orcid":false,"given":"Alessandra","family":"Gianoncelli","sequence":"additional","affiliation":[{"name":"ELETTRA - 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