{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:40:07Z","timestamp":1777873207879,"version":"3.51.4"},"reference-count":61,"publisher":"Frontiers Media SA","issue":"5","license":[{"start":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T00:00:00Z","timestamp":1638489600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Rede Mineira de Bioterismo","award":["0009\/14"],"award-info":[{"award-number":["0009\/14"]}]},{"name":"Funda\u00e7\u00e3o IMEPEN"},{"name":"Rede Mineira de Ensaios Toxicol\u00f3gicos e Farmacol\u00f3gicos","award":["0008\/14"],"award-info":[{"award-number":["0008\/14"]}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Exp Biol Med (Maywood)"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p>\n                    Phosphate chelators are frequently used in patients with chronic kidney disease (CKD). New iron-based chelators remain understudied and offer a promising therapeutic option for the control of bone and mineral disorders of chronic kidney disease (BMD-CKD). We assessed the effect of the phosphorus chelator, chitosan-iron III (CH-FeCl), compared to calcium carbonate (CaCO\n                    <jats:sub>3<\/jats:sub>\n                    ) in BMD-CKD and the potential iron overload in uremic rats. Thirty-two animals were divided into four groups, namely the control, CKD, CKD\/CH-FeCl, and CKD\/CaCO\n                    <jats:sub>3<\/jats:sub>\n                    groups. CKD was induced by adding 0.75% (4\u2009weeks) and 0.1% (3\u2009weeks) adenine to the diet. The chelators were administered from week 3 through week 7. The renal function, BMD-CKD markers, and histomorphometry of the femur were assessed at week 7. The CKD group showed a significant increase in creatinine (83.9\u2009\u00b1\u200918.6 vs. 41.5\u2009\u00b1\u200922.1\u2009\u00b5mol\/L; P\u2009=\u20090.001), phosphate (3.5\u2009\u00b1\u20090.8 vs. 2.2\u2009\u00b1\u20090.2\u2009mmol\/L; P\u2009=\u20090.001), fractional excretion of phosphorus (FEP) (0.71\u2009\u00b1\u20090.2 vs. 0.2\u2009\u00b1\u20090.17; P\u2009=\u20090.0001), and FGF23 (81.36\u2009\u00b1\u200937.16\u2009pg\/mL vs. 7.42\u2009\u00b1\u20091.96; P\u2009=\u20090.011) compared to the control group. There was no accumulation of serum or bone iron after the use of CH-FeCl. The use of chelators reduced the FEP (control: 0.71\u2009\u00b1\u20090.20; CKD\/CH-FeCl: 0.40\u2009\u00b1\u20090.16; CKD\/CaCO\n                    <jats:sub>3<\/jats:sub>\n                    0.34\u2009\u00b1\u20090.15; P\u2009=\u20090.001), without changes in the serum FGF23 and parathyroid hormone levels. Histomorphometry revealed the presence of bone disease with high remodeling in the uremic animals without changes with the use of chelators. The CH-FeCl chelator was efficient in reducing the FEP without iron accumulation, thereby paving the way for the use of this class of chelators in clinical settings in the future.\n                  <\/jats:p>","DOI":"10.1177\/15353702211057280","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T18:26:27Z","timestamp":1638555987000},"page":"446-452","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Iron-based phosphorus chelator: Risk of iron deposition and action on bone metabolism in uremic rats"],"prefix":"10.3389","volume":"247","author":[{"given":"Wander Barros do","family":"Carmo","sequence":"first","affiliation":[{"name":"Laboratory of Experimental Nephrology (LABNEX), Interdisciplinary Nucleus of Laboratory Animal Studies (NIDEAL), Center for Reproductive Biology (CBR), Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil"},{"name":"Interdisciplinary Center for Studies and Research in Nephrology (NIEPEN), Federal University of Juiz de Fora, Juiz de Fora 36036-330, Brazil"},{"name":"Department of Internal Medicine, School of Medicine, Federal University of Juiz de Fora, Juiz de Fora 36038-330, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1rbara Bruna Abreu","family":"Castro","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Nephrology (LABNEX), Interdisciplinary Nucleus of Laboratory Animal Studies (NIDEAL), Center for Reproductive Biology (CBR), Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil"},{"name":"Interdisciplinary Center for Studies and Research in Nephrology (NIEPEN), Federal University of Juiz de Fora, Juiz de Fora 36036-330, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00edsa Cardoso","family":"Manso","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Nephrology (LABNEX), Interdisciplinary Nucleus of Laboratory Animal Studies (NIDEAL), Center for Reproductive Biology (CBR), Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscylla Aparecida Vieira do","family":"Carmo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, Federal University of Juiz de Fora, Juiz de Fora 36038-330, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00f3vis Ant\u00f4nio","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Nucleus for Chemical-Pharmaceutical Investigations (NIQFAR), University of Vale do Itaja\u00ed, Itaja\u00ed 88302-202, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melani Ribeiro","family":"Cust\u00f3dio","sequence":"additional","affiliation":[{"name":"Laboratory of Renal Physiopathology, School of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo 01246-903, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanda","family":"Jorgetti","sequence":"additional","affiliation":[{"name":"Laboratory of Renal Physiopathology, School of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo 01246-903, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8603-1331","authenticated-orcid":false,"given":"Helady","family":"Sanders-Pinheiro","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Nephrology (LABNEX), Interdisciplinary Nucleus of Laboratory Animal Studies (NIDEAL), Center for Reproductive Biology (CBR), Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil"},{"name":"Interdisciplinary Center for Studies and Research in Nephrology (NIEPEN), Federal University of Juiz de Fora, Juiz de Fora 36036-330, Brazil"},{"name":"Department of Internal Medicine, School of Medicine, Federal University of Juiz de Fora, Juiz de Fora 36038-330, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,12,3]]},"reference":[{"key":"bibr1-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002009"},{"key":"bibr2-15353702211057280","first-page":"46","volume":"33","author":"G\u00f3rriz JL","year":"2013","journal-title":"Nefrologia"},{"key":"bibr3-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl718"},{"key":"bibr4-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.115058"},{"key":"bibr5-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq304"},{"key":"bibr6-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-018-4524-7"},{"key":"bibr7-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0171028"},{"key":"bibr8-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2019.06.002"},{"key":"bibr9-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1111\/nep.13031"},{"key":"bibr10-15353702211057280","doi-asserted-by":"publisher","DOI":"10.5414\/CN107764"},{"key":"bibr11-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2005.00293.x"},{"key":"bibr12-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706130"},{"key":"bibr13-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017070772"},{"key":"bibr14-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-014-0224-6"},{"key":"bibr15-15353702211057280","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05170513"},{"key":"bibr16-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-016-1299-z"},{"key":"bibr17-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12891"},{"key":"bibr18-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv006"},{"key":"bibr19-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1159\/000440968"},{"key":"bibr20-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.113.204792"},{"key":"bibr21-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy127"},{"key":"bibr22-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-018-3483-6"},{"key":"bibr23-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180430"},{"key":"bibr24-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-018-1936-4"},{"key":"bibr25-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014020212"},{"key":"bibr26-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.19-0641"},{"key":"bibr27-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1211\/0022357001774552"},{"key":"bibr28-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(01)00727-X"},{"key":"bibr29-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2009.00527.x"},{"key":"bibr30-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12849"},{"key":"bibr31-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1177\/1535370218775035"},{"key":"bibr32-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(88)80099-4"},{"key":"bibr33-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-019-1655-9"},{"key":"bibr34-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.07.017"},{"key":"bibr35-15353702211057280","first-page":"23","volume":"37","author":"Bijvoet OL.","year":"1969","journal-title":"Clin Sci"},{"key":"bibr36-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1805"},{"key":"bibr37-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.04.006"},{"key":"bibr38-15353702211057280","doi-asserted-by":"publisher","DOI":"10.5414\/CNP70296"},{"key":"bibr39-15353702211057280","doi-asserted-by":"publisher","DOI":"10.5414\/CNP63284"},{"key":"bibr40-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-017-1510-x"},{"key":"bibr41-15353702211057280","doi-asserted-by":"publisher","DOI":"10.2174\/1389200216666150206124424"},{"key":"bibr42-15353702211057280","doi-asserted-by":"publisher","DOI":"10.5414\/CNP74004"},{"key":"bibr43-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1111\/nep.13180"},{"key":"bibr44-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2010.01.003"},{"key":"bibr45-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1159\/000348805"},{"key":"bibr46-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1038\/ijos.2015.1"},{"key":"bibr47-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2606"},{"key":"bibr48-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9619253"},{"key":"bibr49-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1016\/S1073-4449(12)80070-7"},{"key":"bibr50-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1111\/nep.13457"},{"key":"bibr51-15353702211057280","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.51.7450"},{"key":"bibr52-15353702211057280","doi-asserted-by":"publisher","DOI":"10.5414\/CN109738"},{"key":"bibr53-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfx252"},{"key":"bibr54-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-018-2531-2"},{"key":"bibr55-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2014.05.078"},{"key":"bibr56-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2012.03.014"},{"key":"bibr57-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1997.tb06099.x"},{"key":"bibr58-15353702211057280","doi-asserted-by":"publisher","DOI":"10.3390\/toxins10060218"},{"key":"bibr59-15353702211057280","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.17-351"},{"key":"bibr60-15353702211057280","doi-asserted-by":"publisher","DOI":"10.5935\/0101-2800.20140042"},{"key":"bibr61-15353702211057280","doi-asserted-by":"publisher","DOI":"10.3390\/toxins10050202"}],"container-title":["Experimental Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15353702211057280","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15353702211057280","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15353702211057280","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:51:42Z","timestamp":1777571502000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ebm-journal.org\/journals\/experimental-biology-and-medicine\/articles\/10.1177\/15353702211057280\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,3]]},"references-count":61,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1177\/15353702211057280"],"URL":"https:\/\/doi.org\/10.1177\/15353702211057280","relation":{},"ISSN":["1535-3702","1535-3699"],"issn-type":[{"value":"1535-3702","type":"print"},{"value":"1535-3699","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,3]]}}}