{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:40:14Z","timestamp":1777873214663,"version":"3.51.4"},"reference-count":45,"publisher":"Frontiers Media SA","issue":"11","license":[{"start":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T00:00:00Z","timestamp":1614384000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18H02331"],"award-info":[{"award-number":["18H02331"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K22352"],"award-info":[{"award-number":["19K22352"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18J22455"],"award-info":[{"award-number":["JP18J22455"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Exp Biol Med (Maywood)"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p>\n                    Sex hormones help in maintaining proper immunity as well as renal homeostasis in mammals, and these multi-functional properties characterize the onset of sex-dependent diseases. To clarify the contribution of sex hormones to autoimmune disease-related renal pathogenesis, BXSB\/MpJ- Yaa was investigated as a murine autoimmune glomerulonephritis model. BXSB\/MpJ- Yaa and its wild-type, BXSB\/MpJ- Yaa\n                    <jats:sup>+<\/jats:sup>\n                    were castrated or sham-operated at three\u2009weeks and examined until six\u2009months of age. Both castrated strains showed significantly lower serum testosterone levels and body weights than sham-operated mice. Castration did not change the disease phenotypes in BXSB\/MpJ- Yaa\n                    <jats:sup>+<\/jats:sup>\n                    . At three\u2009months, both sham-operated and castrated BXSB\/MpJ- Yaa manifested splenomegaly, autoantibody production, and glomerulonephritis, and castrated BXSB\/MpJ- Yaa tended to show heavier spleen weights than the sham-operated group. At six\u2009months, both the treated BXSB\/MpJ- Yaa showed equivalent autoimmune disease conditions; however, castrated mice clearly showed milder glomerular sclerotic lesions than the sham-operated groups. Urinary albumin excretion in castrated BXSB\/MpJ- Yaa was significantly milder than in sham-operated mice at four\u2009months, but those of both the treated BXSB\/MpJ- Yaa were comparable at six\u2009months. The examined renal histopathological indices in parietal epithelial cells were remarkably altered by castration. Briefly, castration decreased the height of parietal epithelial cells and total parietal epithelial cell number in BXSB\/MpJ- Yaa at six\u2009months. For immunostaining, parietal epithelial cells facing the injured glomeruli of BXSB\/MpJ- Yaa expressed CD44, an activated parietal epithelial cell marker, and CD44-positive parietal epithelial cells showed nuclear localization of the androgen receptor and proliferation marker Ki67. CD44- or Ki67-positive parietal epithelial cells were significantly fewer in castrated group than in sham-operated BXSB\/MpJ- Yaa at six\u2009months. Further, quantitative indices for CD44-positive parietal epithelial cell number and frequency in renal corpuscles positively correlated with glomerular sclerotic severity in BXSB\/MpJ- Yaa. In conclusion, androgen seemed to have an effect on both systemic immunity and renal morpho-function; however, the effect on the latter could be more clearly observed in BXSB\/MpJ- Yaa, as parietal epithelial cell activation resulted in glomerular sclerosis.\n                  <\/jats:p>","DOI":"10.1177\/1535370221996010","type":"journal-article","created":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T23:32:21Z","timestamp":1614468741000},"page":"1318-1329","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Castrated autoimmune glomerulonephritis mouse model shows attenuated glomerular sclerosis with altered parietal epithelial cell phenotype"],"prefix":"10.3389","volume":"246","author":[{"given":"Yuki","family":"Otani","sequence":"first","affiliation":[{"name":"Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido 060-0818, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Ichii","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido 060-0818, Japan"},{"name":"Laboratory of Agrobiomedical Science, Faculty of Agriculture, Hokkaido University, Hokkaido 060-8589, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3049-3777","authenticated-orcid":false,"given":"Md. Abdul","family":"Masum","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido 060-0818, Japan"},{"name":"Department of Anatomy, Histology and Physiology, Faculty of Animal Science and Veterinary Medicine, Sher-e-Bangla Agricultural University, Dhaka 1207, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Namba","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido 060-0818, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3204-0245","authenticated-orcid":false,"given":"Teppei","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido 060-0818, Japan"},{"name":"Department of Biological Safety Research, Chitose Laboratory, Japan Food Research Laboratories, Hokkaido 066-0052, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0224-6197","authenticated-orcid":false,"given":"Yasuhiro","family":"Kon","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido 060-0818, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,2,27]]},"reference":[{"key":"bibr1-1535370221996010","first-page":"205","volume":"52","author":"Ortona E","year":"2016","journal-title":"Ann Ist Super Sanit\u00e0"},{"key":"bibr2-1535370221996010","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00475"},{"key":"bibr3-1535370221996010","doi-asserted-by":"publisher","DOI":"10.1177\/0961203311404912"},{"key":"bibr4-1535370221996010","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/604892"},{"key":"bibr5-1535370221996010","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00171.2018"},{"key":"bibr6-1535370221996010","doi-asserted-by":"publisher","DOI":"10.1126\/science.7010603"},{"key":"bibr7-1535370221996010","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-007-0308-1"},{"key":"bibr8-1535370221996010","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.398"},{"key":"bibr9-1535370221996010","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002328"},{"key":"bibr10-1535370221996010","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2018.12.024"},{"key":"bibr11-1535370221996010","doi-asserted-by":"publisher","DOI":"10.1016\/0272-6386(95)90119-1"},{"key":"bibr12-1535370221996010","doi-asserted-by":"publisher","DOI":"10.1159\/000320389"},{"key":"bibr13-1535370221996010","doi-asserted-by":"publisher","DOI":"10.1159\/000334598"},{"key":"bibr14-1535370221996010","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00360.2012"},{"key":"bibr15-1535370221996010","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015070741"},{"key":"bibr16-1535370221996010","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03990318"},{"key":"bibr17-1535370221996010","doi-asserted-by":"publisher","DOI":"10.1177\/0961203308098989"},{"key":"bibr18-1535370221996010","doi-asserted-by":"publisher","DOI":"10.1084\/jem.147.6.1568"},{"key":"bibr19-1535370221996010","doi-asserted-by":"publisher","DOI":"10.3109\/08916939309079229"},{"key":"bibr20-1535370221996010","doi-asserted-by":"publisher","DOI":"10.1159\/000353093"},{"key":"bibr21-1535370221996010","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780221105"},{"key":"bibr22-1535370221996010","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2014.4"},{"key":"bibr23-1535370221996010","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.4049\/jimmunol.125.5.1959","volume":"125","author":"Eisenberg RaDixon FJ.","year":"1980","journal-title":"J Immunol"},{"key":"bibr24-1535370221996010","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.01.012"},{"key":"bibr25-1535370221996010","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.09.020"},{"key":"bibr26-1535370221996010","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.01.037"},{"key":"bibr27-1535370221996010","first-page":"2229","volume":"6","author":"Roche PJ","year":"1992","journal-title":"Mol Endocrinol"},{"key":"bibr28-1535370221996010","doi-asserted-by":"publisher","DOI":"10.1038\/srep32611"},{"key":"bibr29-1535370221996010","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0003"},{"key":"bibr30-1535370221996010","unstructured":"Lin TF. 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