{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T06:42:22Z","timestamp":1784616142491,"version":"3.55.0"},"reference-count":49,"publisher":"Frontiers Media SA","issue":"20","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Exp Biol Med (Maywood)"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>Even though smoking has been scarcely studied in osteoarthritis (OA) etiology, it is considered a controversial risk factor for the disease. Exposure to tobacco smoke has been reported to promote oxidative stress (OS) as part of the damage mechanism. The aim of this study was to assess whether smoking increases cartilage damage through the generation of OS. Peripheral blood (PB) and synovial fluid (SF) samples from patients with OA were analyzed. The samples were stratified according to smoking habit, Kellgren\u2013Lawrence score, pain, and cotinine concentrations in PB. Malondialdehyde (MDA), methylglyoxal (MGO), advanced protein oxidation products (APOPs), and myeloperoxidase (MPO) were assessed; the activity of antioxidant enzymes such as gamma-glutamyl transferase (GGT), glutathione S-transferase (GST) and catalase (CAT), as well as the activity of arginase, which favors the destruction of cartilage, was determined. When stratified by age, for individuals &lt;60 years, the levels of MDA and APOPs and the activity of MPO and GST were higher, as well as antioxidant system activity in the smoking group (OA-S). A greater degree of pain in the OA-S group increased the concentrations of APOPs and arginase activity ( P &lt; 0.01 and P &lt; 0.05, respectively). Arginase activity increased significantly with a higher degree of pain ( P &lt; 0.01). Active smoking can be an important risk factor for the development of OA by inducing systemic OS in young adults, in addition to reducing antioxidant enzymes in older adults and enhancing the degree of pain and loss of cartilage.<\/jats:p>","DOI":"10.1177\/15353702231199072","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T05:14:03Z","timestamp":1698902043000},"page":"1754-1767","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Effect of smoking on the redox status of knee osteoarthritis: A preliminary study"],"prefix":"10.3389","volume":"248","author":[{"given":"Javier","family":"Fern\u00e1ndez-Torres","sequence":"first","affiliation":[{"name":"Laboratorio de L\u00edquido Sinovial, Instituto Nacional de Rehabilitaci\u00f3n \u201cLuis Guillermo Ibarra Ibarra,\u201d Ciudad de M\u00e9xico, C.P. 14389, M\u00e9xico"},{"name":"Departamento de Biolog\u00eda, Facultad de 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