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Dysregulated and excessive inflammatory responses are major underlying causes of viral pneumonia severity and morbidity, including aberrant host immune responses and increased risk for secondary bacterial infections. Currently available antiviral therapies have not substantially reduced the risk of severe viral pneumonia for these pathogens. Thus, new therapeutic approaches that can promote resolution of the pathogen-initiated inflammation without impairing host defense would represent a significant advance. Recent research has uncovered the potential for specialized pro-resolving mediators (SPMs) to transduce multipronged actions for the resolution of serious respiratory viral infection without increased risk for subsequent host susceptibility to bacterial infection. Here, we review recent advances in our understanding of SPM production and SPM receptor signaling in respiratory virus infections and the intriguing potential of harnessing SPM pathways to control excess morbidity and mortality from IAV and RSV pneumonia.<\/jats:p>","DOI":"10.1177\/15353702231199082","type":"journal-article","created":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T08:12:20Z","timestamp":1697271140000},"page":"1635-1644","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Respiratory viral infection and resolution of inflammation: Roles for specialized pro-resolving mediators"],"prefix":"10.3389","volume":"248","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5319-0210","authenticated-orcid":false,"given":"Luciana P","family":"Tavares","sequence":"first","affiliation":[{"name":"Pulmonary and Critical Care Medicine Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Nijmeh","sequence":"additional","affiliation":[{"name":"Pulmonary and Critical Care Medicine Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce D","family":"Levy","sequence":"additional","affiliation":[{"name":"Pulmonary and Critical Care Medicine Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,10,14]]},"reference":[{"key":"bibr1-15353702231199082","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)33293-2"},{"key":"bibr2-15353702231199082","first-page":"2","volume":"42","author":"Moghadami M","year":"2017","journal-title":"Iran J Med Sci"},{"key":"bibr3-15353702231199082","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8122048"},{"key":"bibr4-15353702231199082","first-page":"487","volume":"2","author":"Boyd AR","year":"2011","journal-title":"Aging Dis"},{"key":"bibr5-15353702231199082","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202102-209ST"},{"key":"bibr6-15353702231199082","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97943"},{"key":"bibr7-15353702231199082","volume":"7","author":"Serhan CN","year":"2014","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"bibr8-15353702231199082","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00026.2017"},{"key":"bibr9-15353702231199082","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30129-0"},{"key":"bibr10-15353702231199082","doi-asserted-by":"publisher","DOI":"10.1093\/jtm\/taad032"},{"key":"bibr11-15353702231199082","unstructured":"ICTV. 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