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Recent preclinical studies indicate that prolonged seizure- or brain injury-induced BBB dysfunction and subsequent perivascular inflammation may play an important role in post-traumatic epileptogenesis. In turn, perivascular inflammation can further sustain BBB dysfunction. In genetic epilepsies, such as tuberous sclerosis complex and other related epileptogenic developmental pathologies, there is an association between the underlying gene mutation, BBB dysfunction, and perivascular inflammation, but evidence for a causal link to epilepsy is lacking. Future neuroimaging studies might shed light on the role of BBB function in different epilepsies and address the potential for disease modification by targeting both the BBB and perivascular inflammation in acquired and genetic epilepsies.<\/jats:p>","DOI":"10.1177\/1535759719844750","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T07:52:18Z","timestamp":1558684338000},"page":"177-181","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":60,"title":["The Roof is Leaking and a Storm is Raging: Repairing the Blood\u2013Brain Barrier in the Fight Against Epilepsy"],"prefix":"10.1177","volume":"19","author":[{"given":"J.A.","family":"Gorter","sequence":"first","affiliation":[{"name":"Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, the 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