{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:55:33Z","timestamp":1790942133022,"version":"4.1.0"},"reference-count":6,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy Curr"],"abstract":"<jats:p>\n                    <jats:boxed-text orientation=\"portrait\" position=\"float\">\n                      <jats:p>\n                        <jats:bold>Quality of life and depressive symptoms in older adults: findings from an integrated epilepsy self-management data set<\/jats:bold>\n                      <\/jats:p>\n                      <jats:p>\n                        Kiriakopoulos ET, Briggs F, Fiorelli N, McGee RE, Johnson EK, Jobst BC, Shegog R, Sepulveda R, Sprulli T, Escoffery C, Quarells RC, McVoy M, Priy S, Adeniyi C, Sajatovic M.\n                        <jats:italic toggle=\"yes\">Epilepsy Behav<\/jats:italic>\n                        . 2026 Jul 16;184:111199. Background: In the U.S., about one million people with active epilepsy are adults aged 55\u2009+\u2009. Older adults with epilepsy (OAWE) experience complex health conditions that compromise quality of life (QOL). The contribution of depressive symptom dimensions to health-related QOL remains underexplored in OAWE. Methods: We analyzed baseline data from 13 epilepsy self-management studies in the CDC-sponsored MEW-DB (Managing Epilepsy Well Database), including adults ages 55 and older (N\u2009=\u2009198). The primary outcome was health-related QOL, assessed via the 10-item Quality of Life in Epilepsy scale (QOLIE-10), which was inverse rank normalized (mean = 0, SD\u2009=\u20091). Primary predictors included the Patient Health Questionnaire (PHQ-9) total score, cognitive and somatic symptom sub scores, and suicide ideation. Multivariable mixed-effects linear regression was used to assess associations. Models included a random intercept for originating study. Results: Participants were x\u0304\u2009=\u200960.8 years (range: 55-79); 60.6% female and 68.7% White. On average, participants had mild depressive symptoms (mean PHQ-9\u2009=\u20098.3). Depressive symptom severity was significantly associated with worse QOL. Cognitive (\u03b2\u2009=\u20090.17 SD, 95% CI: 0.12-0.21, p\u2009=\u20095.6\u2009\u00d7\u200910\n                        <jats:sup>\u221213<\/jats:sup>\n                        ), somatic (\u03b2\u2009=\u20090.19 SD, 95% CI: 0.14-0.23, p\u2009=\u20093.3\u2009\u00d7\u200910\n                        <jats:sup>\u221217<\/jats:sup>\n                        ), and total depressive (PHQ-9 total) symptoms (\u03b2\u2009=\u20090.10 SD, 95% CI: 0.08-0.12, p\u2009=\u20093.8\u2009\u00d7\u200910\n                        <jats:sup>\u221221<\/jats:sup>\n                        ) were associated with worse QOLIE-10 total scores when adjusting for likely confounders. Suicide ideation was not associated with QOLIE-10 (\u03b2\u2009=\u20090.07 SD, 95% CI: \u22120.15 to 0.29, p\u2009=\u20090.51). Past 30-day seizure occurrence was associated with worse total QOLIE-10 only when depressive terms were excluded from the multivariable model (\u03b2\u2009=\u20090.38 SD, 95% CI: 0.05-0.72, p\u2009=\u20090.024). Conclusions: Among OAWE, depressive symptoms are strongly linked to reduced QOL. These findings underscore the importance of integrated mental health screening and intervention for OAWE.\n                      <\/jats:p>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1177\/15357597261490444","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:37:16Z","timestamp":1790692636000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Older and Wiser or More Complex?"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4792-8055","authenticated-orcid":false,"given":"Danielle A.","family":"Becker","sequence":"first","affiliation":[{"name":"The Ohio State University Wexner Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6631a1"},{"key":"e_1_3_2_3_2","volume-title":"Institute of Medicine (US) Committee on the Public Health Dimensions of the Epilepsies","year":"2012","unstructured":"Institute of Medicine (US) Committee on the Public Health Dimensions of the Epilepsies. National Academies Press (US); 2012."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2026.111199"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2017.11.006"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2003.08.028"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)33064-8"}],"container-title":["Epilepsy Currents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15357597261490444","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15357597261490444","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15357597261490444","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:16:49Z","timestamp":1790939809000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15357597261490444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":6,"alternative-id":["10.1177\/15357597261490444"],"URL":"https:\/\/doi.org\/10.1177\/15357597261490444","relation":{},"ISSN":["1535-7597","1535-7511"],"issn-type":[{"value":"1535-7597","type":"print"},{"value":"1535-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]},"article-number":"15357597261490444"}}