{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T14:56:41Z","timestamp":1780930601469,"version":"3.54.1"},"reference-count":50,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Imaging"],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:p>\n                    The value of combined L-( methyl-[\n                    <jats:sup>11<\/jats:sup>\n                    C]) methionine positron-emitting tomography (MET-PET) and magnetic resonance imaging (MRI) with regard to tumor extent, entity prediction, and therapy effects in clinical routine in patients with suspicion of a brain tumor was investigated. In n = 65 patients with histologically verified brain lesions n = 70 MET-PET and MRI (T1-weighted gadolinium-enhanced [T1w-Gd] and fluid-attenuated inversion recovery or T2-weighted [FLAIR\/T2w]) examinations were performed. The computer software \u201cvisualization and analysis framework volume rendering engine (Voreen)\u201d was used for analysis of extent and intersection of tumor compartments. Binary logistic regression models were developed to differentiate between World Health Organization (WHO) tumor types\/grades. Tumor sizes as defined by thresholding based on tumor-to-background ratios were significantly different as determined by MET-PET (21.6 \u00b1 36.8 cm\n                    <jats:sup>3<\/jats:sup>\n                    ), T1w-Gd-MRI (3.9 \u00b1 7.8 cm\n                    <jats:sup>3<\/jats:sup>\n                    ), and FLAIR\/T2-MRI (64.8 \u00b1 60.4 cm\n                    <jats:sup>3<\/jats:sup>\n                    ; P &lt; .001). The MET-PET visualized tumor activity where MRI parameters were negative: PET positive tumor volume without Gd enhancement was 19.8 \u00b1 35.0 cm\n                    <jats:sup>3<\/jats:sup>\n                    and without changes in FLAIR\/T2 10.3 \u00b1 25.7 cm\n                    <jats:sup>3<\/jats:sup>\n                    . FLAIR\/T2-MRI visualized greatest tumor extent with differences to MET-PET being greater in posttherapy (64.6 \u00b1 62.7 cm\n                    <jats:sup>3<\/jats:sup>\n                    ) than in newly diagnosed patients (20.5 \u00b1 52.6 cm\n                    <jats:sup>3<\/jats:sup>\n                    ). The binary logistic regression model differentiated between WHO tumor types (fibrillary astrocytoma II n = 10 from other gliomas n = 16) with an accuracy of 80.8% in patients at primary diagnosis. Combined PET and MRI improve the evaluation of tumor activity, extent, type\/grade prediction, and therapy-induced changes in patients with glioma and serve information highly relevant for diagnosis and management.\n                  <\/jats:p>","DOI":"10.1177\/1536012116687651","type":"journal-article","created":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T00:59:37Z","timestamp":1485997177000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Multimodal Imaging of Patients With Gliomas Confirms\n                    <sup>11<\/sup>\n                    C-MET PET as a Complementary Marker to MRI for Noninvasive Tumor Grading and Intraindividual Follow-Up After Therapy"],"prefix":"10.1177","volume":"16","author":[{"given":"Kai R.","family":"Laukamp","sequence":"first","affiliation":[{"name":"European Institute for Molecular Imaging, Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster, Munster, Germany"},{"name":"Department of Radiology, University Hospital of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Lindemann","sequence":"additional","affiliation":[{"name":"Department of Computer Science, Visualization and Computer Graphics Research Group, Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster, Munster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Weckesser","sequence":"additional","affiliation":[{"name":"Departments of Nuclear Medicine, Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster, Munster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Hesselmann","sequence":"additional","affiliation":[{"name":"Departments of Radiology, Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster, Munster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Ligges","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Clinical Research, Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster, Munster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"W\u00f6lfer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster, Munster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Jeibmann","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster, Munster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastian","family":"Zinnhardt","sequence":"additional","affiliation":[{"name":"European Institute for Molecular Imaging, Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster, Munster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Viel","sequence":"additional","affiliation":[{"name":"European Institute for Molecular Imaging, Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster, Munster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sch\u00e4fers","sequence":"additional","affiliation":[{"name":"European Institute for Molecular Imaging, Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster, Munster, Germany"},{"name":"Departments of Nuclear Medicine, Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster, Munster, Germany"},{"name":"Cells-in-Motion Cluster of Excellence (EXC 1003\u2013CiM), Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster, Munster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Paulus","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster, Munster, Germany"},{"name":"Cells-in-Motion Cluster of Excellence (EXC 1003\u2013CiM), Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster, Munster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Stummer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster, Munster, Germany"},{"name":"Cells-in-Motion Cluster of Excellence (EXC 1003\u2013CiM), Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster, Munster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otmar","family":"Schober","sequence":"additional","affiliation":[{"name":"European Institute for Molecular Imaging, Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster, Munster, Germany"},{"name":"Departments of Nuclear Medicine, Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster, Munster, Germany"},{"name":"Cells-in-Motion Cluster of Excellence (EXC 1003\u2013CiM), Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster, Munster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas H.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"European Institute for Molecular Imaging, Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster, Munster, Germany"},{"name":"Departments of Nuclear Medicine, Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster, Munster, Germany"},{"name":"Cells-in-Motion Cluster of Excellence (EXC 1003\u2013CiM), Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster, Munster, Germany"},{"name":"Department of Geriatric Medicine, Johanniter Hospital, Evangelische Kliniken, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,1,24]]},"reference":[{"key":"bibr1-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1083696"},{"key":"bibr2-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0243-4"},{"key":"bibr3-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/not301"},{"key":"bibr4-1536012116687651","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.110.084210"},{"key":"bibr5-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890715)64:2<442::AID-CNCR2820640217>3.0.CO;2-S"},{"key":"bibr6-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70181-2"},{"key":"bibr7-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nov118"},{"key":"bibr8-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-012-2295-5"},{"key":"bibr9-1536012116687651","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.113.131516"},{"key":"bibr10-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1602\/neurorx.2.2.333"},{"key":"bibr11-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2014.03.026"},{"key":"bibr12-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.6.947"},{"key":"bibr13-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nov148"},{"key":"bibr14-1536012116687651","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2006.104.2.238"},{"issue":"8","key":"bibr15-1536012116687651","first-page":"1293","volume":"45","author":"Pirotte B","year":"2004","journal-title":"J Nucl Med"},{"key":"bibr16-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.04.050"},{"key":"bibr17-1536012116687651","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.107.048082"},{"key":"bibr18-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.01.055"},{"key":"bibr19-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nos300"},{"key":"bibr20-1536012116687651","doi-asserted-by":"publisher","DOI":"10.3171\/2012.12.FOCUS12336"},{"key":"bibr21-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1016\/0969-8043(95)00181-C"},{"key":"bibr22-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-013-2895-x"},{"key":"bibr23-1536012116687651","first-page":"115","volume-title":"Res Sci Comput 2003 G\u00f6ttingen, Ger Gesellschaft f\u00fcr wissenschaftliche Datenverarbeitung","author":"Vollmar S","year":"2004"},{"key":"bibr24-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1109\/MCG.2009.130"},{"key":"bibr25-1536012116687651","unstructured":"Lindemann F, Laukamp KR, Jacobs A, Hinrichs K. Interactive Comparative Visualization of Multimodal Brain Tumor Segmentation Data. Eurographics - Vision, Modeling, and Visualization; 2013:105\u2013112. http:\/\/dx.doi.org\/10.2312\/PE.VMV.VMV13.105-112. Eurographics \u2013 European Association for Computer Graphics."},{"key":"bibr26-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-004-1705-8"},{"key":"bibr27-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1007\/s002590050208"},{"key":"bibr28-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1109\/34.295913"},{"key":"bibr29-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1109\/TVCG.2010.208"},{"key":"bibr30-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2004.828354"},{"key":"bibr31-1536012116687651","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2013"},{"key":"bibr32-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nor054"},{"key":"bibr33-1536012116687651","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3324"},{"key":"bibr34-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0b013e328361f598"},{"key":"bibr35-1536012116687651","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.065904"},{"key":"bibr36-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-009-1219-5"},{"key":"bibr37-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.07.002"},{"key":"bibr38-1536012116687651","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.113.123836"},{"key":"bibr39-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-007-0557-4"},{"key":"bibr40-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-008-0847-5"},{"key":"bibr41-1536012116687651","doi-asserted-by":"publisher","DOI":"10.3171\/2008.4.17569"},{"key":"bibr42-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.06.043"},{"key":"bibr43-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000338949.94496.85"},{"key":"bibr44-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0262"},{"key":"bibr45-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/3.3.193"},{"key":"bibr46-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2014.02.006"},{"key":"bibr47-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-013-1145-x"},{"key":"bibr48-1536012116687651","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-013-1308-9"},{"issue":"9","key":"bibr49-1536012116687651","first-page":"1975","volume":"27","author":"Law M","year":"2006","journal-title":"AJNR Am J Neuroradiol"},{"key":"bibr50-1536012116687651","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.110.074773"}],"container-title":["Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1536012116687651","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1536012116687651","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1536012116687651","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:27:29Z","timestamp":1777703249000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1536012116687651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,1]]},"references-count":50,"alternative-id":["10.1177\/1536012116687651"],"URL":"https:\/\/doi.org\/10.1177\/1536012116687651","relation":{},"ISSN":["1535-3508","1536-0121"],"issn-type":[{"value":"1535-3508","type":"print"},{"value":"1536-0121","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,1]]},"article-number":"1536012116687651"}}