{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:16:24Z","timestamp":1778825784630,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["10606\/2016-2"],"award-info":[{"award-number":["10606\/2016-2"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Imaging"],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>\n                      Xerostomia is a well-known complication after iodine-131 (\n                      <jats:sup>131<\/jats:sup>\n                      I) therapy for thyroid carcinoma. It is currently insufficiently understood how the dose and biodistribution of\n                      <jats:sup>131<\/jats:sup>\n                      I relates to salivary gland toxicity, and whether this is consistent for all salivary glands within a single patient. Prostate-specific membrane antigen (PSMA) positron emission tomography\/computed tomography (PET\/CT) was recently introduced as a new tool to evaluate the relative loss of vital acinar cells in individual salivary glands. We aimed to assess gland-specific salivary gland toxicity after\n                      <jats:sup>131<\/jats:sup>\n                      I-therapy using PSMA PET\/CT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Five patients with differentiated thyroid cancer underwent [\n                      <jats:sup>68<\/jats:sup>\n                      Ga]Ga-PSMA-11 PET\/CT to evaluate their eligibility for peptide radioligand therapy with [\n                      <jats:sup>177<\/jats:sup>\n                      Lu]Lu-PSMA-617. Uptake patterns in salivary glands were evaluated visually and quantitatively as an indicator of vital acinar cell loss after prior\n                      <jats:sup>131<\/jats:sup>\n                      I-therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Four of 5 patients demonstrated significant lowered uptake in at least one salivary gland, after receiving at least 2\n                      <jats:sup>131<\/jats:sup>\n                      I-treatments. Asymmetric loss of vital acinar cells occurred by gland type (parotid\/submandibular) and location (right\/left). The other salivary glands in these patients and all salivary glands in the fifth patient showed normal uptake, demonstrating high intrapatient and interpatient variability.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      <jats:sup>131<\/jats:sup>\n                      I-therapy can induce salivary gland toxicity with high inter- but also high intrapatient variation among separate gland locations, which can be assessed with PSMA PET\/CT. This new technique offers potential to guide further development and evaluation of protective measures in patients receiving\n                      <jats:sup>131<\/jats:sup>\n                      I-therapy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1536012120934992","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T13:28:01Z","timestamp":1593782881000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["PSMA PET\/CT Identifies Intrapatient Variation in Salivary Gland Toxicity From Iodine-131 Therapy"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3947-5575","authenticated-orcid":false,"given":"Vineet","family":"Mohan","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Antoni van Leeuwenhoek, The Netherlands Cancer Institute, Amsterdam, the Netherlands"},{"name":"Department of Radiation Oncology, Antoni van Leeuwenhoek, The Netherlands Cancer Institute, Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wouter V.","family":"Vogel","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Antoni van Leeuwenhoek, The Netherlands Cancer Institute, Amsterdam, the Netherlands"},{"name":"Department of Radiation Oncology, Antoni van Leeuwenhoek, The Netherlands Cancer Institute, Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerlof D.","family":"Valk","sequence":"additional","affiliation":[{"name":"Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan P.","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Antoni van Leeuwenhoek, The Netherlands Cancer Institute, Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marnix G. E. H.","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Radiology, University Medical Center Utrecht, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart","family":"de Keizer","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Radiology, University Medical Center Utrecht, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,7,3]]},"reference":[{"key":"bibr1-1536012120934992","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2015.09.001"},{"key":"bibr2-1536012120934992","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.169888"},{"key":"bibr3-1536012120934992","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0106"},{"key":"bibr4-1536012120934992","doi-asserted-by":"publisher","DOI":"10.1089\/105072503321582060"},{"key":"bibr5-1536012120934992","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2007.0107"},{"key":"bibr6-1536012120934992","doi-asserted-by":"publisher","DOI":"10.4236\/abb.2014.55049"},{"key":"bibr7-1536012120934992","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0571"},{"key":"bibr8-1536012120934992","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021544"},{"key":"bibr9-1536012120934992","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-200211000-00003"},{"key":"bibr10-1536012120934992","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509343143"},{"key":"bibr11-1536012120934992","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.191031"},{"key":"bibr12-1536012120934992","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2018.01.011"},{"key":"bibr13-1536012120934992","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000002161"},{"key":"bibr14-1536012120934992","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aac4441"},{"key":"bibr15-1536012120934992","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-200606000-00004"},{"key":"bibr16-1536012120934992","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev278"},{"key":"bibr17-1536012120934992","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.01.062"},{"key":"bibr18-1536012120934992","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22302"},{"key":"bibr19-1536012120934992","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-010-1532-z"},{"issue":"6","key":"bibr20-1536012120934992","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3941\/jrcr.v9i6.2220","volume":"9","author":"Gonzalez ME","year":"2015","journal-title":"J Radiol Case Rep"},{"key":"bibr21-1536012120934992","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e31818130ff"},{"key":"bibr22-1536012120934992","volume-title":"False-Positive Radioiodine Scans in Thyroid Cancer","author":"Shapiro B"},{"key":"bibr23-1536012120934992","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0000000000000034"},{"key":"bibr24-1536012120934992","doi-asserted-by":"publisher","DOI":"10.1118\/1.3602459"},{"key":"bibr25-1536012120934992","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-016-3084-7"},{"key":"bibr26-1536012120934992","doi-asserted-by":"publisher","DOI":"10.1186\/s13550-018-0408-2"},{"key":"bibr27-1536012120934992","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics11110560"}],"container-title":["Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1536012120934992","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1536012120934992","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1536012120934992","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:28:29Z","timestamp":1777703309000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1536012120934992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,1]]},"references-count":27,"alternative-id":["10.1177\/1536012120934992"],"URL":"https:\/\/doi.org\/10.1177\/1536012120934992","relation":{},"ISSN":["1535-3508","1536-0121"],"issn-type":[{"value":"1535-3508","type":"print"},{"value":"1536-0121","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,1]]},"article-number":"1536012120934992"}}