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A MEDLINE search using \u201cdextran,\u201d \u201cvascular surgery,\u201d and \u201cantiplatelet therapy\u201d as keywords was performed for English-language articles. Further references were obtained through cross-referencing the bibliography cited in each work. Dextran is commonly used in carotid endarterectomy (CEA) patients where the embolic rate is reduced by 46%, resulting in fewer procedure-related strokes. As a prophylactic agent against thrombosis, multiple randomized studies have reported its benefit over other antithrombotic medications. Dextran is also particularly useful in \u201cdifficult\u201d infragenicular lower extremity bypasses where artificial grafts (such as polytetrafluoroethylene [PTFE] or umbilical vein) are used in the setting of poor outflow vessels, or those with composite grafts and small-caliber venous conduits. Distal bypasses with adjunctive procedures (eg, arteriovenous fistula or anastomotic cuffs) also have a better outcome with the addition of dextran. Dextran has numerous important implications in vascular surgery, in particular with CEA patients or \u201cdifficult\u201d infragenicular bypasses. Its effectiveness with endovascular stents remains unknown.<\/jats:p>","DOI":"10.1177\/153857440403800601","type":"journal-article","created":{"date-parts":[[2006,3,31]],"date-time":"2006-03-31T16:34:30Z","timestamp":1143822870000},"page":"483-491","source":"Crossref","is-referenced-by-count":39,"title":["Efficacy of Dextran Solutions in Vascular Surgery"],"prefix":"10.1177","volume":"38","author":[{"given":"Farshad","family":"Abir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siamak","family":"Barkhordarian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bauer E.","family":"Sumpio","sequence":"additional","affiliation":[{"name":"New Haven, 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