{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:52:51Z","timestamp":1777942371741,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vasc Endovascular Surg"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:p>Heparin use, both prophylactically and therapeutically, is prevalent among hospitalized patients. Patients on heparin may develop a thrombocytopenia that is self-limited. Fewer patients develop a heparin-induced thrombocytopenia that can cause severe bleeding and thrombosis owing to intravascular platelet aggregation. The authors present a case report of heparininduced thrombocytopenia in a patient who underwent aortic arch and aortic valve replacement that resulted in bilateral above-knee amputations. The patient developed limb ischemia related to heparin-associated thrombosis, but had a delay in antibody seroconversion. Early and accurate diagnosis of heparin-induced thrombocytopenia requires a high clinical suspicion and may be present despite the absence of serum antibodies.<\/jats:p>","DOI":"10.1177\/153857440604000212","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T23:03:41Z","timestamp":1182467021000},"page":"161-164","source":"Crossref","is-referenced-by-count":1,"title":["Bilateral Lower Extremity Gangrene Requiring Amputation Associated with Heparin-Induced Thrombocytopenia"],"prefix":"10.1177","volume":"40","author":[{"given":"Brian P.","family":"Dickinson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel A.","family":"De Ugarte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd D.","family":"Reil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryce D.","family":"Beseth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter F.","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Los Angeles, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,3,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199505183322003"},{"key":"atypb2","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1365-2141.1995.tb08346.x","volume":"89","author":"Chong BH","year":"1995","journal-title":"Br J Haematol"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/0268-960X(88)90032-X"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1614206"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(96)90074-X"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(96)90150-9"},{"key":"atypb7","first-page":"368","volume":"37","author":"Harris KA","year":"1994","journal-title":"Can J Surg"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-200102000-00011"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.4.361"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.15.1849"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.14.1838"}],"container-title":["Vascular and Endovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/153857440604000212","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/153857440604000212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:47:14Z","timestamp":1777704434000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/153857440604000212"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["10.1177\/153857440604000212"],"URL":"https:\/\/doi.org\/10.1177\/153857440604000212","relation":{},"ISSN":["1538-5744","1938-9116"],"issn-type":[{"value":"1538-5744","type":"print"},{"value":"1938-9116","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}