{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:52:15Z","timestamp":1777942335254,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vasc Endovascular Surg"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p>Purpose To assess baseline and follow-up plasma concentrations of metalloproteinase-9 (MMP-9), MMP-2, and tissue inhibitor of metalloproteinase-2 (TIMP-2) in patients undergoing carotid thromboendarterectomy (TEA) in relation to tissue expression and diagnostic features.<\/jats:p>\n                  <jats:p>Basic Methods Using sandwich enzyme-linked immunosorbent assay, plasma levels of enzymes were determined in 15 patients undergoing carotid TEA. Tissue sections were incubated with specific antibodies and fluorescence intensity was analyzed.<\/jats:p>\n                  <jats:p>Principal Findings MMP-9 levels were higher in patients with carotid stenosis versus controls, significantly in those with cerebral lesions at neuroimaging. MMP-9 levels decreased in 93.4% of the patients at 1 month. MMP-2 levels tended to increase 30 days after surgery. TIMP-2 showed no difference.<\/jats:p>\n                  <jats:p>Conclusions High concentrations of MMP-9 found in patients with carotid stenosis and cerebral lesions suggest that MMP-9 assay could be useful in the evaluation of all carotid lesions to help identify those at highest risk of a neurologic event.<\/jats:p>","DOI":"10.1177\/1538574407307405","type":"journal-article","created":{"date-parts":[[2007,12,31]],"date-time":"2007-12-31T14:57:52Z","timestamp":1199113072000},"page":"516-521","source":"Crossref","is-referenced-by-count":16,"title":["Metalloproteinase Expression in Carotid Plaque and Its Correlation With Plasma Levels Before and After Carotid Endarterectomy"],"prefix":"10.1177","volume":"41","author":[{"given":"Maurizio","family":"Taurino","sequence":"first","affiliation":[{"name":"U.O.C. Chirurgia Vascolare, \"S. Andrea\" Hospital, 2nd Medical School, University of Rome \"La Sapienza,\" Rome, Italy, maurizio.taurino@ uniroma1.it"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Raffa","sequence":"additional","affiliation":[{"name":"U.O.C. Diagnostica Cellulare \u201cS. Andrea\" Hospital, 2nd Medical School, University of Rome \u201cLa Sapienza,\" Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Mastroddi","sequence":"additional","affiliation":[{"name":"U.O.C. Chirurgia Vascolare, \"S. Andrea\" Hospital, 2nd Medical School, University of Rome \"La Sapienza,\" Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Visco","sequence":"additional","affiliation":[{"name":"U.O.C. Diagnostica Cellulare \u201cS. Andrea\" Hospital, 2nd Medical School, University of Rome \u201cLa Sapienza,\" Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Rizzo","sequence":"additional","affiliation":[{"name":"U.O.C. Chirurgia Vascolare, \"S. Andrea\" Hospital, 2nd Medical School, University of Rome \"La Sapienza,\" Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Rosaria","family":"Torrisi","sequence":"additional","affiliation":[{"name":"U.O.C. Diagnostica Cellulare \u201cS. Andrea\" Hospital, 2nd Medical School, University of Rome \u201cLa Sapienza,\" Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Faraglia","sequence":"additional","affiliation":[{"name":"U.O.C. Chirurgia Vascolare, \"S. Andrea\" Hospital, 2nd Medical School, University of Rome \"La Sapienza,\" Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,1,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.2.415"},{"key":"atypb2","volume-title":"La mortalit\u00e0 per cause nelle regioni italiane 1998-2000","year":"2002"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.1.40"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(97)90084-2"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.8.2125"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1007\/s10016-005-5018-6"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2000.1278"},{"key":"atypb8","first-page":"89","volume":"53","author":"Corrado E.","year":"2005","journal-title":"Minerva Cardioangiol"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00250-2"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.05.039"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2005.08.009"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2005.03.002"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000058700.41738.12"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108153250701"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1007\/BF02135282"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2004.06.023"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2004.02.001"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2004.10.011"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(97)00859-8"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1999.5794"}],"container-title":["Vascular and Endovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1538574407307405","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1538574407307405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:48:42Z","timestamp":1777704522000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1538574407307405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,1]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["10.1177\/1538574407307405"],"URL":"https:\/\/doi.org\/10.1177\/1538574407307405","relation":{},"ISSN":["1538-5744","1938-9116"],"issn-type":[{"value":"1538-5744","type":"print"},{"value":"1938-9116","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,1]]}}}