{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:55:05Z","timestamp":1777942505100,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:00:00Z","timestamp":1374192000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Endovascular Surg"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>Ischemia\u2013reperfusion (I\/R) injury negatively affects the outcome of surgical interventions for amputated or severely traumatized extremities. This study aimed to evaluate the protective role of l-carnitine on the contractile properties of fast-twitch (extensor digitorum longus [EDL]) and slow-twitch (soleus [SOL]) skeletal muscles following I\/R-induced injury in a rat model. Rats were divided into 4 groups (1) saline pretreatment, (2) l-carnitine pretreatment, (3) saline pretreatment and I\/R, and (4) l-carnitine pretreatment and I\/R. Twitch and tetanic contractions in the EDL and SOL muscles in each group were recorded. Additionally, a fatigue protocol was performed in these muscles. Twitch and tetanic contraction amplitudes were lower in the EDL and SOL muscles in which I\/R was induced ( P &lt; .01). l-Carnitine pretreatment significantly increased tetanic contraction amplitude in the SOL muscles following I\/R ( P &lt; .01) but not in the EDL muscles. l-Carnitine pretreatment did not alter the fatigue response in any of the muscles.<\/jats:p>","DOI":"10.1177\/1538574413496481","type":"journal-article","created":{"date-parts":[[2013,7,20]],"date-time":"2013-07-20T00:32:05Z","timestamp":1374280325000},"page":"540-545","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>L<\/scp>\n                    -Carnitine Pretreatment Protects Slow-Twitch Skeletal Muscles in a Rat Model of Ischemia\u2013Reperfusion Injury"],"prefix":"10.1177","volume":"47","author":[{"given":"Mert","family":"Demirel","sequence":"first","affiliation":[{"name":"Department of Plastic Reconstructive and Aesthetic 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