{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:54:33Z","timestamp":1777942473140,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T00:00:00Z","timestamp":1395100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Endovascular Surg"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p>Symptomatic internal carotid artery (ICA) occlusion with hemodynamic impairment remains a dismal disease when untreated. In this prospective, single-center, controlled study, we investigated the feasibility, safety, and long-term outcome of stenting by endovascular recanalization for patients with chronic ICA occlusion. Forty patients with symptomatic chronically occluded ICA were assigned to receive endovascular recanalization (group A, n = 18) or conservative management (group B, n = 22). The primary end point was 100% complete recanalization of the primary occlusion at 60 minutes, and secondary end points were improvement in neurologic function and cognitive function. Patients in the 2 groups were comparable in demographic and baseline characteristics. Successful recanalization was achieved in 88.9% (16 of 18) of patients with the restoration of Thrombolysis in Myocardial Ischemia\/Thrombolysis in Cerebral Ischemia 2 or 3 flow. There was no procedural or new cerebral ischemic event. Improvement in brain perfusion was observed in 12 (12 of 18, 75%) patients on single-photon emission computed tomography. Improvement in neurologic function defined as a reduction of \u22654 points on the National Institutes of Health Stroke Scale (NIHSS) at 6 months was observed in group A (baseline, 6.83 \u00b1 3.01 vs 6 months, 2.61 \u00b1 1.20; P &lt; .01) and group B (baseline, 6.05 \u00b1 2.75 vs 6 months, 4.77 \u00b1 1.69; P &lt; .05). A significant difference in NIHSS scores was noted between group A and B at 1, 3, and 6 months ( P &lt; .05 or .001). Improvement in cognitive function defined as an increase of \u22658 on the Montreal Cognitive Assessment (MoCA) was observed in group A at 3 and 6 months (baseline, 14.67 \u00b1 3.56 vs 3 months, 24.17 \u00b1 3.55 and 6 months, 24.72 \u00b1 2.85; P &lt; .01). Significant improvement in MoCA was also observed in group B ( P &lt; .01). Furthermore, a significant difference in MoCA scores was noted between group A and B at 1, 3, and 6 months ( P &lt; .05 or .001). Endovascular recanalization is feasible and safe for patients with symptomatic chronic carotid artery occlusion. Successful carotid artery stenting can improve neurological function and global cognitive function than nonrevascularization.<\/jats:p>","DOI":"10.1177\/1538574414525863","type":"journal-article","created":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T20:59:42Z","timestamp":1395176382000},"page":"305-310","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":47,"title":["Neurocognitive Improvement After Carotid Artery Stenting in Patients With Chronic Internal Carotid Artery Occlusion"],"prefix":"10.1177","volume":"48","author":[{"given":"Yi-Ling","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Renji Hospital, Shanghai Jiaotong University Medical College, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie-Qing","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Renji Hospital, Shanghai Jiaotong University Medical College, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng-Wen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Renji Hospital, Shanghai Jiaotong University Medical College, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Renji Hospital, Shanghai Jiaotong University Medical College, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Renji Hospital, Shanghai Jiaotong University Medical College, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Renji Hospital, Shanghai Jiaotong University Medical College, Shanghai, 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