{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:38:43Z","timestamp":1777941523524,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2016,5,16]],"date-time":"2016-05-16T00:00:00Z","timestamp":1463356800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Endovascular Surg"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec>\n                    <jats:title>Rationale:<\/jats:title>\n                    <jats:p>Restenosis due to intimal hyperplasia (IH) is a major clinical issue that affects the success of lower limb endovascular surgery. After 1 year, restenosis occurs in 40% to 60% of the treated vessels. The possibility to reduce IH using local antiproliferative drugs, such as taxols, has been the rationale for the clinical applications of drug-eluting stents and drug-eluting balloons (DEBs). The purpose of this study was to evaluate the clinical and instrumental efficacy of DEBs versus simple percutaneous transluminal angioplasty (PTA) in patients affected by chronic limb ischemia (CLI) with tibial artery \u201cde novo\u201d lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective analysis was performed and included all consecutive patients who underwent endovascular treatment for CLI in our centers between January 2011 and March 2013. Inclusion criteria were (1) \u201cde novo\u201d tibial artery stenosis and (2) Rutherford class &gt;4. Lesions were further divided by TransAtlantic Inter-Societal Consensus (TASC) classification into groups A, B, C, and D.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Between January 2010 and March 2013, a total of 138 patients underwent simple PTA or DEB for CLI, and the groups were clinically and demographically homogenous. We decided to use DEBs in 70 cases. An improvement in the Rutherford Scale in cumulative and single TASC lesions classification was better in the DEB group (74% vs 51%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .024) at 24 months than in the PTA group. In the DEB group, the increase in ankle\u2013brachial index was significantly higher than in the PTA group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .039).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our experience in addition to the existing literature supports the use of DEB in patients with CLI Rutherford class &gt;3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1538574416647500","type":"journal-article","created":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T20:12:32Z","timestamp":1463515952000},"page":"304-308","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["The Mid-Term Clinical Follow-Up Using Drug-Eluting Balloons on Tibial Artery \u201cDe Novo\u201d Lesions in Patients With Critical Limb Ischemia"],"prefix":"10.1177","volume":"50","author":[{"given":"Valerio","family":"Tolva","sequence":"first","affiliation":[{"name":"Department of Surgery, IRCCS Istituto Auxologico Italiano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Casana","sequence":"additional","affiliation":[{"name":"Department of Surgery, IRCCS Istituto Auxologico Italiano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Huibers","sequence":"additional","affiliation":[{"name":"Nuffield Department of Surgical Sciences, John Radcliff Hospital, University of Oxford, Oxford, United Kingdom"},{"name":"Department of Vascular Surgery, University Medical Center, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Parati","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Neural and Metabolic Sciences, S.Luca Hospital, IRCCS Istituto Auxologico Italiano, Milan, Italy"},{"name":"Department of Health Sciences, University of Milano-Bicocca, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Policlinico Di Monza Hospital, Monza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lea","family":"Cireni","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Policlinico Di Monza Hospital, Monza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Ferrero","sequence":"additional","affiliation":[{"name":"Vascular and Endovascular Surgery Unit, Mauriziano Umberto Hospital, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Halliday","sequence":"additional","affiliation":[{"name":"Nuffield Department of Surgical Sciences, John Radcliff Hospital, University of Oxford, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,5,16]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/1526602815592206"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.12.037"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1583\/10-3242.1"},{"issue":"2","key":"e_1_3_2_5_2","first-page":"82","article-title":"Evolving modalities for femoropopliteal interventions","volume":"16","author":"Ansel GM","year":"2009","unstructured":"Ansel GM, Lumsden AB. 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