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We report the case of a 38-year-old female patient with an acute onset of severe RP in both hands secondary to systemic sclerosis. Medical treatment failed, so a novel approach by a combination of a modified distal sympathectomy and injection of A botulinum toxin on digital neuromuscular bundles was performed. Remission of the pain occurred immediately after the procedure and 45 days later she had complete healing of the digital wounds and recovered full mobilization of both hands. The patient remained asymptomatic 6 month after the procedure, and a Doppler ultrasound showed tri-phasic flows distal to the surgical site. This novel technique is described, and a brief review of the literature is performed.<\/jats:p>","DOI":"10.1177\/15385744211005663","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T04:22:30Z","timestamp":1618806150000},"page":"766-771","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Novel Combined Approach for Digital Necrosis Secondary to Raynaud\u2019s Phenomenon"],"prefix":"10.1177","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7669-2988","authenticated-orcid":false,"given":"Diego Herrera","family":"Vegas","sequence":"first","affiliation":[{"name":"Centro de Estudios M\u00e9dicos e Investigaciones Cl\u00ednicas (C.E.M.I.C.), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8548-6833","authenticated-orcid":false,"given":"Mario Alejandro","family":"Fabiani","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Medicine and Health Sciences, Monterrey, Nuevo Le\u00f3n, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5101-1541","authenticated-orcid":false,"given":"Mauricio","family":"Gonzalez-Urquijo","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Medicine and Health Sciences, Monterrey, Nuevo Le\u00f3n, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agust\u00edn","family":"Bignotti","sequence":"additional","affiliation":[{"name":"Centro de Estudios M\u00e9dicos e Investigaciones Cl\u00ednicas (C.E.M.I.C.), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Ser\u00e9","sequence":"additional","affiliation":[{"name":"Centro de Estudios M\u00e9dicos e Investigaciones Cl\u00ednicas (C.E.M.I.C.), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Salvadores","sequence":"additional","affiliation":[{"name":"Centro de Estudios M\u00e9dicos e Investigaciones Cl\u00ednicas (C.E.M.I.C.), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,4,19]]},"reference":[{"key":"bibr1-15385744211005663","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2009.05.003"},{"key":"bibr2-15385744211005663","first-page":"403","volume":"128","author":"Hutchinson J","year":"1901","journal-title":"Med Press Circ"},{"key":"bibr3-15385744211005663","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-006389"},{"issue":"3","key":"bibr4-15385744211005663","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/s00108-007-2011-x","volume":"49","author":"Muller-Ladner U","year":"2008","journal-title":"Internist (Berl)"},{"issue":"4","key":"bibr5-15385744211005663","first-page":"642","volume":"32","author":"Bogoch ER","year":"2005","journal-title":"J Rheumatol"},{"issue":"1","key":"bibr6-15385744211005663","first-page":"141","volume":"158","author":"Marie I","year":"2008","journal-title":"Br J Dermatol"},{"key":"bibr7-15385744211005663","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.09004.x"},{"key":"bibr8-15385744211005663","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2009.08.002"},{"issue":"2","key":"bibr9-15385744211005663","first-page":"269","volume":"25","author":"Yee AM","year":"1998","journal-title":"J Rheumatol"},{"key":"bibr10-15385744211005663","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-9053(05)80035-3"},{"key":"bibr11-15385744211005663","doi-asserted-by":"publisher","DOI":"10.1016\/0266-7681(91)90007-B"},{"key":"bibr12-15385744211005663","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-821X(88)80070-7"},{"key":"bibr13-15385744211005663","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2002.123330"},{"key":"bibr14-15385744211005663","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.05.080"},{"key":"bibr15-15385744211005663","doi-asserted-by":"publisher","DOI":"10.1016\/0885-3924(95)00015-Q"},{"key":"bibr16-15385744211005663","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.2001.19960675.x"},{"issue":"11","key":"bibr17-15385744211005663","first-page":"1","volume":"28","author":"Monti D","year":"1980","journal-title":"Min Cardioang"},{"key":"bibr18-15385744211005663","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(80)80104-3"},{"key":"bibr19-15385744211005663","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(05)80419-8"},{"key":"bibr20-15385744211005663","volume-title":"The Autonomic Nervous System: Morphological, Comparative, Clinical and Surgical Aspects","author":"Pick J","year":"1970"},{"key":"bibr21-15385744211005663","unstructured":"Jones NF. 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