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Of the many complications that arise from ATAAD is malperfusion, which is the result of true lumen compression secondary to the dissection, and it is one of the most dangerous complications. Left untreated, malperfusion can eventually compromise circulation to the vascular beds of almost all vital organs. Clinicians must consider the diagnosis of malperfusion promptly following a diagnosis of acute aortic dissection. The outcomes post-surgery for patients with ATAAD with concomitant malperfusion remains poor, despite mortality for aortic surgery improving over time. Optimal management for ATAAD with associated malperfusion has yet to be implemented, further research is warranted to improve the detection and management of this potentially fatal pathology. In this review, we explore the literature surrounding the complications of malperfusion in ATAAD and the various symptom presentations, investigations, and management strategies available.<\/jats:p>","DOI":"10.1177\/15385744211017116","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T07:57:19Z","timestamp":1622102239000},"page":"721-729","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Malperfusion in Acute Type A Aortic Dissection: Management Strategies"],"prefix":"10.1177","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4698-8483","authenticated-orcid":false,"given":"Mona","family":"Jaffar-Karballai","sequence":"first","affiliation":[{"name":"Department of Medicine, St George\u2019s University of London, Cranmer Terrace, Tooting, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tien Thuy","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Medicine, St George\u2019s University of London, Cranmer Terrace, Tooting, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oyinkan","family":"Oremakinde","sequence":"additional","affiliation":[{"name":"Department of Medicine, St George\u2019s University of London, Cranmer Terrace, Tooting, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somama","family":"Zafar","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of East Anglia, Norwich Research Park, Norwich, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5507-5841","authenticated-orcid":false,"given":"Amer","family":"Harky","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Liverpool Heart and Chest Hospital, Liverpool, United Kingdom"},{"name":"Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool, Heart and Chest Hospital, Liverpool, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,5,27]]},"reference":[{"key":"bibr1-15385744211017116","unstructured":"Aortic dissection - Symptoms and causes - Mayo Clinic. 2017. 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