{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:35:58Z","timestamp":1788449758910,"version":"build-2803163510"},"reference-count":6,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T00:00:00Z","timestamp":1670630400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Endovascular Surg"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>A previously healthy 13 year-old boy presented with acute-onset headaches, aphasia and right-sided hemiparesis. Imaging showed cerebral ischemic infarction due to bilateral carotid occlusion, and investigation for stroke etiology diagnosed homocystinuria. Homocystinuria is an autosomal recessive condition that affects the metabolism of the amino acid methionine due to an enzyme deficiency. This disorder involves multiple organs systems, and complications include thromboembolic events, ectopia lentis, mental retardation, and skeletal abnormalities. The early diagnosis and treatment of hyperhomocystinemia can significantly improve outcomes. Therefore, metabolic screening for homocystinuria is strongly recommended for children presenting with stroke.<\/jats:p>","DOI":"10.1177\/15385744221144978","type":"journal-article","created":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T08:21:17Z","timestamp":1670660477000},"page":"417-419","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Angiopathy and Stroke Associated with Homocystinuria in Childhood"],"prefix":"10.1177","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0683-5418","authenticated-orcid":false,"given":"Zeferino","family":"Demartini","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Universidade Federal do Parana Hospital de Clinicas, Curitiba, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9849-5109","authenticated-orcid":false,"given":"Pedro Juan","family":"Furtado Neves","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Universidade Federal do Parana Hospital de Clinicas, Curitiba, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre Luis Santos do","family":"Carmo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Universidade Federal do Parana Hospital de Clinicas, Curitiba, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Antoniuk","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Universidade Federal do Parana Hospital de Clinicas, Curitiba, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle Caldas","family":"Bufara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Universidade Federal do Parana Hospital de Clinicas, Curitiba, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Clarice Bartosievicz","family":"Prestes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Universidade Federal do Parana Hospital de Clinicas, Curitiba, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liara Bohnert","family":"Rodrigues MD","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Universidade Federal do Parana Hospital de Clinicas, Curitiba, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Ziemba","family":"Araujo","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Universidade Federal do Parana Hospital de Clinicas, Curitiba, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriane","family":"Cardoso-Demartini","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Universidade Federal do Parana Hospital de Clinicas, Curitiba, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,12,10]]},"reference":[{"key":"bibr1-15385744221144978","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2010.05.017"},{"key":"bibr2-15385744221144978","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.633119"},{"key":"bibr3-15385744221144978","doi-asserted-by":"publisher","DOI":"10.1016\/0887-8994(96)00117-8"},{"key":"bibr4-15385744221144978","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.217935"},{"key":"bibr5-15385744221144978","doi-asserted-by":"publisher","DOI":"10.1159\/000093579"},{"key":"bibr6-15385744221144978","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-016-9979-0"}],"container-title":["Vascular and Endovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15385744221144978","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15385744221144978","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15385744221144978","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:33:35Z","timestamp":1777703615000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15385744221144978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,10]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1177\/15385744221144978"],"URL":"https:\/\/doi.org\/10.1177\/15385744221144978","relation":{},"ISSN":["1538-5744","1938-9116"],"issn-type":[{"value":"1538-5744","type":"print"},{"value":"1938-9116","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,10]]}}}